MICRO: a Registry Study in Patients With Microvascular Angina
RecruitingNCT04612322
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The evidence above demonstrates that microvascular dysfunction is an important determinant of patient prognosis, which however remains poorly classified. Given the high burden of disease and the severity of the functional impairment in these patients, the lack of a clear definition for this disease has a potentially large clinical importance. It is important to better describe the phenotype of these patients, identify the predictors of prognosis, and determine the impact of diagnosis.
Study details
- Official title
- A Multicenter Registry on the Diagnosis of Patients With Chronic Angina and no Angiographic Coronary Artery Stenosis
- Conditions
- Microvascular Disease
- Interventions
- Device: Assessment of microvascular function with intracoronary hemodilution
- Sponsor
- Johannes Gutenberg University Mainz
- Start date
- 2020-10-10
- Primary completion
- 2024-10-10
- Sex
- All
- Age range
- from 18 Years to 85 Years
- Results posted
- No results posted in this snapshot
- Countries
- Germany
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Age ≥ 18 and \<85 years. * Chronic coronary syndrome (including patients with anginal equivalents) * Angina CCS class II-IV * Evidence of reversible ischemia on non-invasive testing * Availability of the following measurements: 1. Index of microvascular resistances (IMR), 2. Resting full-cycle ratio (RFR), 3. Fractional flow reserve (FFR), 4. Coronary flow reserve (CFR) * Willingness to participate and ability to understand read and signed the informed consent document before the procedure Exclusion Criteria: At least one of the following: * Pregnancy and or lactation. * Medical or psychological conditions that would jeopardize an adequate and orderly participation. * Left ventricular ejection fraction lower than 30% * Previous coronary artery bypass surgery (CABG) to all major branches in the LAD and left circumflex (LCX) territory, such that IMR cannot be measured * Decompensated congestive heart failure (CHF) * Chronic or acute renal failure with creatinine \>2mg/dl * Severe valvular heart disease * Patients with comorbidities limiting life expectancy to less than one year
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04612322