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Efficacy of Adaptogens in Patients With Long COVID-19

CompletedPhase 2, Phase 3NCT04795557
View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

The aim of this clinical trial of a fixed combination of standardized extracts from Rhodiola rosea roots, Schisandra chinensis berry and Eleutherococcus senticosus root (ADAPT-232) in COVID-19 patients is to demonstrate possible efficacy of adjuvant treatment with ADAPT-232 in decreasing the duration of the convalescence, alleviation of fatigue, headache, attention deficit, difficult and rapid respiration, depression, anxiety and other symptoms of Long COVID-19 during rehabilitation period.

Study details

Official title
Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial
Conditions
  • Covid19
Interventions
  • Dietary supplement: ADAPT-232 oral solution
  • Other: Placebo oral solution
Sponsor
Swedish Herbal Institute AB
Collaborators
National Family Medicine Training Centre, Georgia; Tbilisi State Medical University; Phytomed AB
Start date
2021-04-19
Primary completion
2021-11-11
Sex
All
Age range
from 18 Years
Results posted
No results posted in this snapshot
Countries
Georgia
Total sites listed
1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * COVID-19 patients with confirmed diagnosis based on positive SARS-Cov-2 test and the symptom of at least three of Long COVID-19 symptoms including: fatigue, headache, respiration problems (dyspnea or polypnea), sweat, cognitive disorders (attention, memory, anxiety and depression), loss of smell (anosmia) and taste (ageusia), cough, pain in joints. muscles and chest. * Post COVID-19 patients discharged from Covid Hotels isolation, after hospitals and Intensive Care Unit (ICU) admission. * Subjects must be under observation or admitted to a controlled facility or hospital (home quarantine is not sufficient). * Able to take medication alone. * Able to give informed consent. Exclusion Criteria: * Post COVID-19 patients discharged from Covid Hotels isolation, after hospitals and Intensive Care Unit (ICU) admission and Long Covid Symptoms longer that 3 months. * Patient admitted already under invasive mechanical ventilation; * Patient admitted with severe acute respiratory syndrome and diagnosed with an etiologic agent other than SARS-CoV-2; * Renal failure requiring dialysis or creatinine ≥ 2.0mg/dl; * Tube feeding or parenteral nutrition. * Respiratory decompensation requiring mechanical ventilation. * Uncontrolled diabetes type 2. * Autoimmune disease. * Pregnant or lactating women. * Taking antibiotics for a reason other than COVID-19 at enrollment; * Has a chronically weakened immune system (AIDS, lymphoma, chemo-radio- corticosteroid therapy, immunosuppressive pathology); * Was treated with chemo-radio-corticosteroid therapy in the last 6 months; * Has active cancer; * Taking immunosuppressive drugs (e.g. anti-rejection treatment after organ transplant); * Already participating in another clinical trial; * Has any other condition that would prevent safe participation in the study.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04795557