Enhancing Analgesia in Chronic Pain Through Exercise
Unknown statusNot applicableNCT04862871
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Background: Current pain management strategies for pediatric patients are not integrating the analgesic potential of movement-based therapies. To date, experiencing a painful stimulus has been known to disrupt motor activity in an attempt to minimize injury. However, physical activity, even when it increases ongoing pain initially, has been shown to significantly reduce pain symptoms eventually through neuromodulation. In both acute and chronic pain cohorts, exercise protocols and neuromodulation paradigms have produced exercise-related analgesia. Problem: It is not currently understood which brain regions are implicated in exercise-based analgesia and what brain regions moderate this response. Approach: The investigators intend to provide a physical activity intervention designed to promote exercise-induced analgesia. This intervention will be performed in a group of pediatric subjects with Chronic Widespread Pain Disorder. An exercise (n=10), no exercise (n=10) and healthy control (n=10) group will be recruited. Aims: This study has three aims: (1) To understand how thermal pain sensitivity, pain symptoms and motor performance are impacted in patients with chronic pain after an exercise-based intervention. (2) To evaluate the brain regions involved in a simple motor task as well as how motor activity influences activity in pain regions of the brain. (3) To evaluate the network structure of the brain, with special emphasis on motor and pain regions, in youth with a pain disorder who have undergone an exercise-based intervention. Exercise-based therapy in pediatric subjects with a chronic pain condition is predicted to reduce pain symptom reporting through biasing activity in pain regions during motor performance. Significance: Findings from this investigation will address the clinical side of pain management strategies and provide potential therapeutic targets and feasibility data. The investigators anticipate that findings will show how pain and motor regions of t…
Study details
- Official title
- Enhancing Analgesia in Chronic Pain Through Exercise: Responsivity of Sensory-Motor Networks and Factors That Moderate the Analgesic Response
- Conditions
- Interventions
- Behavioral: Physical Activity - Pediatric Pain Rehabilitation Center
- Sponsor
- Boston Children's Hospital
- Start date
- 2022-04-01
- Primary completion
- 2022-08
- Sex
- All
- Age range
- from 10 Years to 24 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Otherwise healthy participants between the ages of 10 and 24 * Actively on the waitlist for, or having completed the exercise program at the PPRC * Comprehension of instructions * Parental consent for minors * Weight less than 250 lbs - limit of MRI table * Clinical diagnosis of Chronic Widespread Pain Exclusion Criteria: * Preventative medications and opioids * Metallic implants that will pose harm to the subject (e.g., pacemaker) and/or affect the dat (e.g., braces) * Significant medical disease (systemic or CNS). * Active suicidality, psychosis, diagnosed eating disorders, and/or other severe clinically diagnosed neuro-psychiatric conditions * Pregnant * Claustrophobia
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04862871