Safety and Efficacy Study of Matrilin-3 Pretreated Autologous Adipose Derived Mesenchymal Stem Cells Implantation in Chronic Low Back Pain Patients With Lumbar Intervertebral Disc Degeneration

Inclusion Criteria: * Male and female patients aged 19-70 years * Among the subjects with low back pain, conventional conservative treatment is performed, but the back pain or hip pain persists for more than 3 months, and it is determined that the cause of the back pain is a degenerative disc (MRI checks for a degenerative disc) * Has Oswestry Disability score(ODI) ≥ 30% * Has Visual Analogue Scale(VAS) ≥ 4 * Between lumbar 1-sacral 1, Magnetic Resonance Imaging (MRI) grade according to the Pfirrmann classification is 3\~4. * Has one or two degenerative lumbar discs identified by MRI (Confirmation of low back pain due to disc through various nerve block procedures.) * Consent was prepared for stem cell administration Exclusion Criteria: * Patient requiring surgery due to severe pain in lower extremities due to severe nerve compression due to severe lumbar stenosis or prolapse of lumbar nucleus. * patient with spinal instability, spondylitis, or vertebral fracture * type 3 Modic change is in an endplate * Patient whose disc height has decreased by more than 1/2 due to severe disc degenerative change * Patient with severe osteoporosis (The average value of the T score in the lumbar spine bone density test is -2.5 or less) * has undergone surgery, such as disc resection, on the disc to which the cells will be administered * Patient who received lumbar epidural steroid injection 3 weeks before cell administration * Pregnant or lactating women * Among female patients who are likely to become pregnant during the clinical trial, who do not use medically acceptable methods of contraception * medically acceptable methods of contraception: condom, Oral contraception lasting for at least 3 months, Has received an infusion pill before 3 months, using an injectable or implantable contraceptive, or installed an intrauterine contraceptive device * has a history of psychiatry or who are currently undergoing treatment, who judged that it is difficult to proceed with the clinical trial under the judgment of the researcher * Patient with drug or alcohol addiction who cannot understand the purpose and method of this clinical trial * Patient who participated in other clinical trials within 3 months prior to participation in the trial * Patient who may affect this clinical trial due to serious medical conditions (hypertension not controlled by drugs, diabetes not controlled by drugs, cirrhosis, kidney failure, tumors) * Patient with a history of malignant tumors within the last…