Corticospinal and Motor Behavior Responses After Physical Therapy Intervention in Patients With Chronic Low Back Pain.
CompletedNot applicableNCT05156242
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study aims to 1) determine the immediate effects of transcranial direct current stimulation (tDCS) on corticospinal excitability, lumbar multifidus muscle (LM) activation, as well as lumbar stability in patients with chronic low back pain (CLBP), 2) determine the immediate effects of neuromuscular electrical stimulation (NMES) on corticospinal excitability, LM activation, as well as lumbar stability in patients with CLBP, 3) compare the effectiveness of 6-week intervention program among tDCS priming with motor control exercise (MCE), NMES priming with MCE, and MCE alone in patients with CLBP, and 4) determine the associations among corticospinal excitability, LM activation, lumbar stability, movement patterns, and clinical outcomes in patients with CLBP.
Study details
- Official title
- Corticospinal and Motor Behavior Responses After 6-week Transcranial Direct Current Stimulation and Neuromuscular Electrical Stimulation Combined With Motor Control Exercises in Patients With Chronic Low Back Pain
- Conditions
- Interventions
- Device: Active-tDCS priming MCE
- Device: Sham-tDCS priming MCE
- Device: NMES priming MCE
- Other: Conventional physical therapy
- Sponsor
- Mahidol University
- Collaborators
- University of South Carolina
- Start date
- 2021-09-03
- Primary completion
- 2024-10-31
- Sex
- All
- Age range
- from 18 Years to 40 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Thailand
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: The inclusion criteria for individuals without a history of low back pain. 1. Between the ages of 18 and 40 2. No previous history of low back pain in lifetime. The inclusion criteria for patients with CLBP individuals. 1. Between the ages of 18 and 40. 2. Having low back pain over 3 months or a recurrent pattern of LBP at least two episodes that interfered with activities of daily living and/or required treatment. This information will be obtained by interview during subjective examination. Exclusion Criteria: 1. History of seizure for either the subject or any family member 2. Implanted pacemaker 3. Clinical signs of systemic disease 4. Definitive neurologic signs including pain, weakness or numbness in the lower extremity 5. Previous spinal surgery 6. Diagnosed osteoporosis, severe spinal stenosis, and/or inflammatory joint disease 7. Any lower extremity condition that would potentially alter trunk movement 8. Vestibular dysfunction 9. Extreme psychosocial involvement 10. Body mass index (BMI) greater than 30 kg/m2 11. Active treatment of another medical illness that would preclude participation in any aspect of the study 12. Menstruation or pregnancy (for female subject) 13. Diagnosed herniated nucleus pulposus (HNP) 14. Contraindications for TMS and tDCS including open wound, infection, lesions, arteriosclerosis, history of haemophilia or demand-type pacemaker 15. Acute cerebral hemorrhage 16. Medications that can interfere the effect of tDCS including sodium channel blocker, calcium channel blocker, NMDA receptor antagonist
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05156242