Shifting Away From Pain: Neurocognitive Approach to Explain and Predict Recovery Following Whiplash Injury
TerminatedNCT05161767
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Around half of the patients with neck pain after trauma (whiplash) will develop chronic pain. Understanding the transition from acute to chronic pain after whiplash is a priority since will help to identify those which patients are likely to fully recover and who do not. In the last years, there have been a call for an investigation of new biomarkers; particularly in brain structure and function. Alterations in the structure of the brain (gray matter, white matter and cortical thickness) as well as the brain function have been found in people with chronic WAD; which are also correlated with pain, disability and symptoms of central sensitization such as hyperalgesia. Previous research has found structural and functional brain differences between people who develop chronic low back pain compared to those who recovered; but research in this vein is still lacking in people with whiplash. Consequently, this study aims to examine the neural correlates of recovery following whiplash injury.
Study details
- Official title
- Shifting Away From Pain: Neurocognitive Approach to Explain and Predict Recovery Following Whiplash Injury
- Conditions
- Whiplash Injuries
- Interventions
- Diagnostic test: Brain MRI (neuroimaging)
- Sponsor
- University Ghent
- Start date
- 2020-01-06
- Primary completion
- 2024-01-10
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Belgium
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Whiplash patients Inclusion Criteria: * Neck pain within 4 weeks after the trauma * Native Dutch speaker * Refraining from consuming caffeine, alcohol and nicotine in the hour before the MRI scans in both measurement times Exclusion Criteria: * Neuropathic pain * Being pregnant * A history of a chronic pain syndrome * Chronic fatigue syndrome * Fibromyalgia * Cardiovascular disorders * Epilepsy * Endocrinological disorders * Rheumatic disorders * Psychiatric disorders * History of neck surgery * Loss of consciousness during/after the whiplash trauma * MRI incompatible health condition (e.g., pacemaker, metal prosthetic devices) * Claustrophobia. Healthy volunteers: (matched for age and gender). Additional exclusion criteria include for healthy volunteers * a history of a chronic pain syndrome * a pain condition in the last six months for which treatment was sought
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05161767