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Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation

RecruitingPhase 3NCT05196503
View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of new techniques to prevent this chronic pain. Certain well-tolerated techniques, such as the administration of plasma enriched with platelets and fibrin (PRF), are increasingly used in regenerative medicine for their anti-inflammatory and analgesic properties. Thus, a periradicular intraoperative application of PRF may have an analgesic effect on the intensity of residual postsurgical neuropathic pain after disc herniation surgery.

Study details

Official title
Efficacy of Platelet Rich Fibrin in the Prevention of Residual Neuropathic Pain Following Disc Herniation Surgery
Interventions
  • Biological: Treatment
Sponsor
University Hospital, Strasbourg, France
Start date
2022-02-23
Primary completion
2022-02-23
Sex
All
Age range
from 18 Years
Results posted
No results posted in this snapshot
Countries
France
Total sites listed
1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)
Inclusion criteria: * Patient, male or female, \>18 years old at the time of signing informed consent; * Patient for whom a diagnosis of radiculopathy on lumbar disc herniation has been made, and for whom surgery has been scheduled in the Neurosurgery department; * Patient affiliated to a social security health insurance scheme; * Patient able to understand the objectives and risks of research and to give informed, dated and signed consent; * Patient having been informed of the results of the prior medical examination; * Women of childbearing age provided that a negative blood pregnancy test is recorded at the inclusion visit and effective contraception used throughout the study. Exclusion criteria: * Patient with a history of lumbar spinal surgery (multiple herniated discs, herniated disc other than lumbar); * Patient with HIV, active cancer, HBV, HCV (verified by interview); * Patient on long-term systemic corticosteroid therapy; * Patient with an ASA score \> 3 during the consultation with the anesthesiologist; * Inability to give the patient informed information (patient in an emergency or life-threatening situation, difficulties in understanding); * Patient in exclusion period (determined by a previous or ongoing study); * Subject under safeguard of justice; * Subject under curatorship; * Pregnancy; * Breastfeeding.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05196503