Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
Unknown statusNot applicableNCT05439707
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) occur in 11-51% of patients after surgery, and its prevalence increases with age. The occurrence of delirium is associated with increased morbidity and mortality, prolonged hospital stay, worse functional recovery. Orthopedic procedures and specifically joint replacements have been considered as a major risk for development of chronic postsurgical pain (CPSP). Approximately 13-44% of patients will develop CPSP after knee or hip arthOpioid abuseroplasty. CPSP may cause the discomfort, distress, disability and opioid abuse. Mounting evidence has revealed that inflammation triggered by surgical trauma plays a key role in POD, POCD and CPSP. Recent studies found that vagus nerve stimulation showed the suppression of inflammation. In this study, the effect of perioperative transauricular vagus nerve stimulation on the prognosis of patients undergoing arthroplasty will be investigated, providing potential solutions for the prevention and treatment of postoperative cognitive dysfunction, postoperative delirium and chronic postsurgical pain.
Study details
- Official title
- Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on Postoperative Delirium, Postoperative Cognitive Dysfunction and Chronic Postsurgical Pain in Patients Undergoing Arthroplasty.
- Conditions
- Postoperative Cognitive Dysfunction
- Postoperative Delirium
- Chronic Post Operative Pain
- Interventions
- Device: transaricular vagus nerve stimulation
- Device: fake transaricular vagus nerve stimulation
- Sponsor
- Xuzhou Central Hospital
- Collaborators
- The Affiliated Hospital of Xuzhou Medical University; The First People's Hospital of Xuzhou
- Start date
- 2022-10-01
- Primary completion
- 2024-07-01
- Sex
- All
- Age range
- from 50 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- China
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * 50 to 80 years old. * ASA grade I-Ⅲ. * elective knee or hip replacement. Exclusion Criteria: * Mini-Mental State Examination (MMSE) score \< 23. * Education years\<7. * Peptic ulcer disease, serious cardiac-cerebral vascular disease. * Neurological or psychiatric disorders. * History of drug and alcohol abuse. * Hepatic and/or kidney dysfunction. * BMI\>35. * Patients on antidepressants. * ASA \>Ⅲ.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05439707