Fatigue in Chronic Pain - Cognition, Emotional Aspects, Biomarkers, and Neuronal Correlates

Brief summary (from the registry)

The investigators will examine mental/cognitive as well as cognitive functions (executive functions, attention functions, processing speed, learning and memory) in 200 patients with chronic pain and 36 healthy controls. Mental fatigue will be measured with questionnaires and cognitive fatigue and cognitive functions with neuropsychological tests. As studies on patients with mild traumatic brain injury has shown that fatigue is associated with altered communication (connectivity) in the brain's attention-related networks, brain connectivity will be measure in 24 patients (women only) and 22 healthy female controls using functional magnetic resonance imaging (fMRI) technology. During the fMRI examination, participants will also perform a 20-minute vigilance task in a scanner. Studies have also shown that inflammatory biomarkers may be related to chronic pain, but inflammatory biomarkers has not been studied in relation to objective measures regarding cognition, fatigue and connectivity changes. Therefore, the patients and controls performing fMRI will also be examined with immunological biomarkers. In addition to this, a further 14 patients and 14 controls carrying out the neuropsychological testing alone will also be examined for immunological biomarkers. The main objectives are: 1. Do patients with chronic pain show more pronounced self-rated mental fatigue and cognitive fatigue compared to healthy controls and are fatigue measures related to cognitive functions such as process speed and attention functions? 2. What is the relationship between cognitive impairments, mental fatigue, or fatigability and 1. the duration of pain 2. generalization of pain and are they affected by covariates, such as sleep disorders and degree of depression/anxiety? 3. Is there an association between immunological biomarkers and cognitive functions/mental fatigue/cognitive fatigability? 4. Does the connectivity in the brain of patients with chronic pain differ from healthy controls at res…

Study details

Official title

Fatigue in Chronic Pain - Cognitive Functions, Emotional Aspects, Biomarkers and Neuronal Correlates - a Descriptive Comparative Study

Conditions

• Pain
• Fatigue
• Cognitive Impairment

Interventions

• Diagnostic test: Neuropsychological (NPA)
• Other: Imaging
• Diagnostic test: Inflammatory biomarkers

Sponsor

Danderyd Hospital

Collaborators

University Hospital, Umeå; Karolinska Institutet; Umeå University; Linkoeping University

Start date

2018-01-01

Primary completion

2022-12-31

Sex

All

Age range

from 18 Years to 50 Years

Healthy volunteers

true

Results posted

No results posted in this snapshot

Countries

Sweden

Total sites listed

3

Eligibility criteria