Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain

Inclusion Criteria: * Signed informed consent form (ICF) * Diagnosis of solid or liquid cancer made \>= 1 year at any stage in cancer survivorship (specifically, active cancer treatment or no cancer-directed therapy either in clinical remission or with advanced disease) * Prognosis of greater than six months as determined by their primary oncologist * Moderate-to-severe demoralization (score of \>= 10 on the Demoralization Scale-II \[DS-II\]) * Chronic pain (pain lasting \> 3 months) per patient report and score of \>= 5 for average pain level on Brief Pain Inventory * Age \>= 26 years old and ≤85 years old * Availability of a friend or family member into whose care the participant can be released following the drug administration session Exclusion Criteria: * Pregnancy or breastfeeding * Women of childbearing potential (i.e., not permanently sterilized, not postmenopausal) who decline to use a highly effective dual contraceptive method for the duration of the study. Dual contraceptive method use is defined by a use a barrier contraceptive in addition to another method to prevent pregnancy, including sterilization, hormonal methods, intrauterine devices, and hormonal pills. * Age \< 26 years old and \> 85 years old * Poor functional status (Eastern Cooperative Oncology Group \[ECOG\] score of \>= 2) * Major cognitive impairment as determined by principal investigator * Non-fluency in the English language * Personal history of a psychotic disorder or Bipolar disorder type I/II * Active suicidal ideation with intent in the last 3 months (Columbia Suicide Severity Rating Scale suicidal ideation score \> 3) or any suicide attempt in the past year * Current substance use disorder (i.e., present in last six months), of greater than mild severity as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM-V) * History of a seizure disorder in adulthood * Active central nervous system (CNS) metastases or symptomatic CNS infection * Uncontrolled hypertension (mean blood pressure (mmHg) exceeding 139 systolic and 89 diastolic) and heart rate exceeding 90 beats per minute * Clinically significant cardiovascular disease (coronary artery disease, congestive heart failure, arrhythmia, or QTc\>450ms) * Supplemental oxygen requirement * Body mass index =\< 18 * Renal insufficiency as evidenced by creatinine clearance (CrCl) \< 30 mL/min * Concomitant use of drugs known to interact with psilocybin (probenecid, diclofenac) * Consistent use of serotonergic drugs…