Effects of Manual Therapy Combined With Therapeutic Exercise on Brain Biomarkers in Neck Pain
CompletedNot applicableNCT05568394
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Structural brain alterations in pain-related areas have been demonstrated in patients with nonspecific neck pain. While manual therapy combined with therapeutic exercise is an effective management for neck pain, its underlying mechanisms are poorly understood. The primary objective of this trial is to investigate the effects of manual therapy combined with therapeutic exercise on brain imaging biomarkers in patients with chronic nonspecific neck pain. The secondary objectives are to assess neurochemical biomarkers, clinical features of neck pain, cervical range of motion and cervical muscle strength.
Study details
- Official title
- Effects of Manual Therapy Combined With Therapeutic Exercise on Brain Biomarkers in Patients With Chronic Nonspecific Neck Pain: Study Protocol for a Randomized Controlled Trial.
- Conditions
- Interventions
- Other: Manual therapy combinded with therapeutic exercise
- Other: Routine physical therapy
- Sponsor
- Chiang Mai University
- Start date
- 2022-11-15
- Primary completion
- 2023-11-28
- Sex
- All
- Age range
- from 18 Years to 59 Years
- Results posted
- No results posted in this snapshot
- Countries
- Thailand
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * a history of nonspecific neck pain for ≥ 3 months * an average pain intensity over the past week ≥ 35 mm. on a visual analogue scale (VAS) Exclusion Criteria: * a history of head and neck injury or surgery * known or suspected vestibular pathology or dizziness caused by underlying pathology in the ear, brain and sensory nerve pathways (e.g. benign paroxysmal positional vertigo) and/or vascular disorders * any neurological or musculoskeletal condition that could affect the outcomes (e.g., scoliosis, torticollis, myofascial pain syndrome, fibromyalgia and rheumatoid arthritis) * metabolic conditions (e.g., diabetes, obesity (BMI \> 30 kg/m2) and hypertension) * psychological symptoms (e.g., anxiety, depression and schizophrenia) * contraindications to MRI (e.g., pregnancy/breastfeeding, claustrophobia and ferromagnetic implants) * receiving physiotherapy treatment for their neck conditions in the past 12 months.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05568394