Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty
Unknown statusNCT05572307
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Single-celled sequencing for evaluating differences in gene expression patterns in different cell types of the dynamics of a means of this research as a starting point, to study the postoperative delirium and chronic pain at the cellular level changes the contents of a cell, reveal its occurrence and development of the role of gene regulation, find targets and biomarkers, and to provide new ideas for its pathogenesis, To provide theoretical basis support for its prevention, clinical diagnosis and treatment.
Study details
- Official title
- Peripheral Blood Single Cell Sequencing Analysis of Postoperative Delirium (POD) and Chronic Postsurgical Pain (CPSP) in Elderly Patients After Total Knee Arthroplasty
- Conditions
- Postoperative Delirium
- Chronic Postsurgical Pain
- Sponsor
- Xuzhou Central Hospital
- Collaborators
- The Affiliated Hospital of Xuzhou Medical University
- Start date
- 2022-10-30
- Primary completion
- 2023-10-30
- Sex
- All
- Age range
- from 65 Years to 80 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- China
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Age ≥65 years old, regardless of gender. * total knee arthroplasty for the first time. * The ASA classification is I-Ⅲ. Exclusion Criteria: * severe neurological or psychiatric disorders * drug and alcohol abuse * patients on antidepressants * failure and decompensation of vital organs * chronic pain from previous surgery or trauma
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05572307