Effects of Multiple Mega-dose of Vitamin D3 Supplementation on Ameliorating Moderate to Severe Chronic Pain in Hemodialysis Patients
RecruitingNot applicableNCT05667090
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Pain is a major complaint in hemodialysis (HD) patients. Concentrations of parathyroid hormone (PTH) \>250 pg/ml are associated with chronic pain. Visual Analogue Scale (VAS) score which is used to assess the pain severity is positively related to PTH levels. This study is aimed to assess the effects of multiple mega dosages vitamin D supplementations in HD patients with chronic pain. It's a single-center, parallel, double-blind randomized control trial that administrations of 576,000 IU once a week of vitamin D3 for 4 weeks or placebo are for 120 eligible subjects. VAS and laboratory tests including serum concentrations of 25(OH)D, calcium, phosphorus, PTH and C-reactive protein will be evaluated.
Study details
- Official title
- Effects of Multiple Mega-dose of Vitamin D3 Supplementation on Ameliorating Moderate to Severe Chronic Pain in Hemodialysis Patients
- Conditions
- Hemodialysis
- Chronic Pain
- Hyperparathyroidism
- Interventions
- Other: Vitamin D
- Other: Placebo
- Sponsor
- Taipei Medical University Hospital
- Start date
- 2023-03-15
- Primary completion
- 2025-12-31
- Sex
- All
- Age range
- from 20 Years
- Results posted
- No results posted in this snapshot
- Countries
- Taiwan
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Haemodialysis subject ≥ 20 years old 2. iPTH \> 250 pg/mL 3. Chronic pain with visual analogue scale (VAS) score ≥ 4 4. Voluntary to check serum 25(OH)D levels two times by his/her own payment during the study 5. Sign the informed consent Exclusion Criteria: 1. Used to participate in other clinical trials 2. Chronic liver disease 3. Sarcoidosis or multiple myeloma
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05667090