Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders
CompletedNCT05679297
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this observational study is to examine the association between exact lesion location and presence of thalamic CPSP (Central post-stroke pain) in a larger number of patients after thalamic stroke.
Study details
- Official title
- Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders
- Conditions
- Central Post-stroke Pain
- Interventions
- Diagnostic test: Quantitative sensory testing (QST)
- Diagnostic test: Magnetic resonance imaging (MRI)
- Other: Clinical interview/exam
- Other: Follow-up interview
- Sponsor
- University Hospital, Basel, Switzerland
- Collaborators
- European Pain Federation
- Start date
- 2015-05-04
- Primary completion
- 2024-12-27
- Sex
- All
- Age range
- from 18 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Switzerland
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Patients with thalamic central post-stroke pain (CPSP) : Patients fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * History of thalamic stroke (infarction or bleed) * Diagnosis of definite central-post stroke pain (according to the criteria proposed by Klit et al, 2009) * No other chronic pain condition * Age: ≥18 years old 2. Patients with thalamic stroke without CPSP: Patients fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * History of thalamic stroke (infarction or bleed), at least 2 years ago * No chronic pain condition (neither CPSP or other pain condition) * Age ≥18 years old 3. Patients with migraine (other pain condition): Patients fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * History of highly frequent (≥8 monthly migraine days) or chronic migraine (≥15 monthly migraine days). * No history of stroke * Age ≥18 years old 4. Healthy controls: Participants fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * No history of stroke * No chronic pain condition * Age: ≥18 years old Exclusion Criteria: * History of severe neurological, internistic or psychiatric disease * MRI related exclusion criteria: * paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the brain) * Pacemaker * Claustrophobia * Pregnancy
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05679297