Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
RecruitingNCT05701852
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
Study details
- Official title
- Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
- Conditions
- Interventions
- Other: reward learning task
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Start date
- 2023-12-19
- Primary completion
- 2027-05
- Sex
- All
- Age range
- from 18 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin. * For controls: matched to a case on age (±5 years) and sex Exclusion Criteria: * Neurodegenerative or inflammatory neurological pathology * Clinical depressive syndrome * High doses of opioid treatment (greater than 100 mg/day of morphine equivalent) * Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks * Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05701852