Pain Phenotypes in Chronic Pancreatitis
Unknown statusNCT05713344
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Chronic pancreatitis (CP) is characterised by recurrent abdominal pain. The pathological hallmarks of CP is pancreatic stellate cell activation that results in persistent inflammation and progressive fibrosis. It has been shown in various clinical and experimental studies that with disease progression there could be pancreatic neural inflammation, spinal sensitization and eventually alteration in the pain modulating architecture within the brain (widespread sensitization). These events result in different types of pain (nociceptive and neuropathic) in patients with CP, which may dynamically change during disease progression. Since the treatment for different mechanisms are unique, it becomes important to identify the predominant type of pain. Recently, pancreatic quantitative sensory testing (P-QST) has emerged as a valuable tool to identify different types of sensitization. This facility is currently available only in select centers and is being conducted under research protocols. In this study, we propose to: 1. evaluate the patterns of pain in CP and the triggers; 2. identify clinical surrogates of sensitization, i.e. neuropathic pain. The ultimate goal is to apply the best possible pain management strategy based on our research findings for patients with CP in a personalised manner.
Study details
- Official title
- Evaluation of Pain Phenotypes in Chronic Pancreatitis and Identification of Clinical Surrogates of Pancreatic Neuropathy
- Conditions
- Interventions
- Other: Clinical history
- Other: Clinical examination
- Other: Evaluation of quality of life
- Other: Evaluation of mental state
- Diagnostic test: Pancreatic quantitative sensory testing
- Sponsor
- Asian Institute of Gastroenterology, India
- Collaborators
- All India Institute of Medical Sciences; SIDS Hospital and Research Center, Surat; Aalborg University Hospital
- Start date
- 2021-08-01
- Primary completion
- 2023-02-28
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- India
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * At least 3 years of disease (chronic pancreatitis) * Both genders * Able to provide informed consent Exclusion Criteria: * Acute exacerbation of chronic pancreatitis * Moderate to severe abdominal pain at the time of screening * Pancreatic cancer or other malignancies * Use of antidepressants, narcotics, and neuromodulators
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05713344