Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Unknown statusNot applicableNCT05795478
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Chronic postoperative pain is one of the common perioperative complications, which seriously affects the prognosis of patients. Currently, no specific perioperative pain management strategy has been found to be effective in preventing and treating chronic postoperative pain in patients undergoing spinal surgery. At present, oxycodone has been widely recognized in different surgical populations for the control of acute postoperative pain, but its contribution to chronic postoperative pain remains unknown. Meanwhile, whether pregabalin can reduce the occurrence of chronic postoperative pain remains controversial, and whether the combination of the two drugs can control the occurrence of chronic postoperative pain in a more comprehensive way remains unknown. Therefore, we intend to conduct this randomized-controlled, factorial design study to determine the efficacy and safety of oxycodone combined with pregabalin in the treatment of chronic postoperative pain in patients undergoing spinal surgery.
Study details
- Official title
- Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery: a Randomized Control, Double-blinded, Factorial Design Trial
- Conditions
- Chronic Post Operative Pain
- Oxycodone
- Pregabalin
- Postoperative Complications
- Interventions
- Drug: Oxycodone and Pregabalin
- Drug: Oxycodone and placebo capsules
- Drug: Pregabalin and NS
- Drug: placebo capsules and NS
- Sponsor
- Beijing Tiantan Hospital
- Start date
- 2023-10-24
- Primary completion
- 2024-12-31
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- China
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patient undergoing elective spinal surgery * Ages equal to or more than 18 years old * ASA I-III * Signed informed consent Exclusion Criteria: * Previous allergic history to gabapentinoids or oxycodone; * Patients with aphasia or inability to cooperate with scales assessments; * Patients with a diagnosed history of psychiatric disorder; * Known severe insufficiency of vitals(such as heart failure/renal dysfunction/hepatic failure); * Patients treated with gabapentin/pregabalin in the last three months; * History of drug abuse; * Body Mass Index more than 35 kg/㎡; * Pregnant or breastfeeding woman.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05795478