Chronic Pain Rehabilitation in Patients With Small Fiber Neuropathy
Unknown statusNot applicableNCT05798949
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Small fiber neuropathy (SFN) is a condition that is dominated by invalidating neuropathic pain. Pharmacological neuropathic pain treatment is often disappointing, since pain reduction is mostly slight and side effects can be debilitating. Although neuropathic pain is caused by a lesion of the somatosensory system, also psychological factors, such as fear and catastrophizing, appear to play a role in the origin and maintenance of disability in chronic pain. Rehabilitation based on pain education and cognitive behavioral treatment including elements of acceptance and commitment therapy, exposure in vivo or graded activity can be performed to influence these factors. To date no specific rehabilitation programs are available for patients diagnosed with SFN.
Study details
- Official title
- Chronic Pain Rehabilitation in Patients With Small Fiber Neuropathy
- Conditions
- Small Fiber Neuropathy
- Interventions
- Behavioral: Chronic pain rehabilitation: exposure in vivo
- Behavioral: Chronic pain rehabilitation: graded activity
- Behavioral: Chronic pain rehabilitation: acceptance and commitment therapy
- Sponsor
- Academisch Ziekenhuis Maastricht
- Start date
- 2023-03-09
- Primary completion
- 2025-10
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Netherlands
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Aged older than 18 years, * Skin-biopsy proven idiopathic small fiber neuropathy (SFN), * Main goal/purpose to achieve with rehabilitation therapy. Exclusion Criteria: * Are not able to provide written informed consent, * Have an underlying condition of SFN (diabetes, SCN (sodium voltage-gated channel alpha) 9A (subunit 9A) /10A (subunit 10A) /11A (subunit 11A) mutation, hypothyroidism, renal failure, vitamin B12 deficiency, monoclonal gammopathy of undetermined significance, alcohol abuses, malignancies, chemotherapeutic drugs), * Have other neurological disease than SFN that may cause pain in the feet and/or damage to the somatosensory nervous system, are excluded, * Have received any form of cognitive behavioral therapy within the last 6 months will be excluded from this study, * Have insufficient comprehension of the Dutch language.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05798949