The Investigation of Underlying Mechanism of Lumbar Multifidus Muscle Activation Deficits
CompletedNot applicableNCT05961774
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this clinical trial is to investigate mechanism underlying lumbar multifidus muscle (LM) activation deficits in adults with chronic low back pain (CLBP). The main questions it aim to answer is whether motor cortex or muscular level is the underlying mechanism responsible for the LM activation deficits. Participants will: * Undergo cortical excitability measurement using transcranial magnetic stimulation, LM activation measurement using ultrasound imaging, and force measurement using hand-held dynamometer. * Be randomly assigned to either repetitive magnetic stimulation (rTMS) or neuromuscular electrical stimulation (NMES) * Undergo all measurement at post-intervention Researchers will compare within and between groups to see changes in cortical excitability, LM activation, and force.
Study details
- Official title
- The Investigation of Underlying Mechanism of Lumbar Multifidus Muscle Activation Deficits in Adults With Chronic Low Back Pain
- Conditions
- Interventions
- Device: Transcranial magnetic stimulation
- Device: Neuromuscular electrical stimulation
- Sponsor
- Mahidol University
- Collaborators
- National Research Council of Thailand
- Start date
- 2023-03-15
- Primary completion
- 2024-03-14
- Sex
- All
- Age range
- from 18 Years to 40 Years
- Results posted
- No results posted in this snapshot
- Countries
- Thailand
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Male and female age between 18 and 40 years. * Experience of low back pain at least 3 months, or recurrent of back pain for at least two episodes in 6 months that interferes with activities of daily living. Exclusion Criteria: * Spondylolysis, spondylolisthesis, spine tumor and malignancy * Radiculopathy or myelopathy * History of lumbar or abdominal surgery * Pregnancy * Neurological Disease (e.g., stroke, Parkinson, traumatic brain injury, spinal cord injury) * Major cardiovascular diseases (e.g., heart failure, coronary artery diseases, angina pain) * Skin lesion (e.g., skin laceration) on site of stimulation. * Experience of lumbar motor control exercise more than or equal to 2 weeks * Metal implantation sensitive to magnetic field, or cardiac implantations * BMI greater or equal to 30 kg/m2 * Taking any medications that would interfere with brain stimulation (e.g., Calcium channel blockers, Na+ channel blocker, NMDA antagonist, Glutamate receptor antagonist, nicotine uptake)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05961774