Can Electroencephalography (EEG) Identify the Different Dimensions of Pain in Fibromyalgia?
CompletedNCT05962658
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Studies with quantitative electroencephalogram (qEEG) in people with fibromyalgia showed the existence of distinct patterns of brain electrical activity when compared to healthy individuals. Such dysfunctional patterns may be correlated to clinical symptoms of the syndrome as chronic pain and emotional disorders (depression and anxiety). As chronic pain can be considered a multidimensional symptom, its evaluation should consider beyond others, two main dimensions: the sensitive-discriminative dimension and the affective-motivational dimension. Previous studies have been describing distinct brain areas as neural substrates for processing such dimensions of pain. Thus, the identification of electrophysiological biomarkers (i.e., as qEEG measures) allowing to perform an evaluation between dysfunctional patterns of brain electrical activity and different dimensions of pain seems to be a promising path in the search for a better understanding of the syndrome as well as for more individualized and effective therapeutic approaches. Our objective was to investigate whether dysfunctional patterns of brain electrical activity in frontal and central areas of people with fibromyalgia are differently related to dimensions of pain (sensory-discriminative and affective-motivational) and to emotional disorders (depression and anxiety).
Study details
- Official title
- Electrophysiological Biomarkers of Persons With Fibromyalgia and Its Relation With the Sensitive-discriminative and Affective-motivational Dimensions of Pain
- Conditions
- Interventions
- Other: qEEG
- Sponsor
- Universidade Federal de Pernambuco
- Start date
- 2021-04-01
- Primary completion
- 2021-07-31
- Sex
- Female
- Age range
- from 18 Years to 60 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Brazil
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * widespread pain index (WPI) ≥ 7; * symptom severity scale (SS) = 5; * WPI between 4-6 and (iv) SS ≥ 9; * generalized pain, as defined as pain in at least 4 regions of the body; * having been diagnosed with fibromyalgia at least three months ago. Exclusion Criteria: * autoimmune or inflammatory diseases that cause pain, such as rheumatoid arthritis, systemic lupus erythematosus, or inflammatory bowel disease; * history of neurological or psychotic disorders; * cognitive impairment that prevents the conduct of study procedures; * patients with a history of abusive use of alcohol or other illicit drugs; * patients who have any contraindication for the use of the qEEG (excessive seborrhoea, scalp infection or pediculosis).
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05962658