Quantitative Sensory Testing and Occipital Nerve Stimulator
CompletedNot applicableNCT06022848
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The primary aim of this study is to assess the reversibility of a range of psychophysical markers of pain processing in patients with chronic migraine or cluster headache before and after ONS insertion and comparing to patients having a general anaesthetic (GA) for a non-painful aetiology at Barts Health NHS Trust. We will also compare with healthy volunteers not undergoing surgery. To establish whether pain perception alters in patients with chronic migraine/cluster headache having ONS using questionnaires and compare to patients having a general anaesthetic for a non- painful procedure D \& C at Barts Health NHS Trust. Are pain markers (Glutamate, TGF-B1) altered with ONS?
Study details
- Official title
- Does Occipital Nerve Stimulation Alter Pain Response as Measured by Quantitative Sensory Testing in Patients With Chronic Migraine or Cluster Headache
- Conditions
- Migraines
- Interventions
- Procedure: occipital nerve stimulator
- Sponsor
- Barts & The London NHS Trust
- Start date
- 2019-09-01
- Primary completion
- 2026-01-14
- Sex
- All
- Age range
- from 18 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion criteria Subject satisfies standard criteria in the study centre for ONS implantation and the NICE 452 criteria for intractable chronic migraine or cluster headache. Patients who have given their written informed consent. Patient is able and willing to comply with study procedures and follow up schedule. Participants will need a good understanding of the English Language and hence. This is a requirement not just for this research but also for the success of the interventions and the full understanding of QST. Patients undergoing surgery (non-painful complaint) 'dilatation and curettage' (D\&C). Exclusion criteria * Any inclusion criteria not met * Female patients of childbearing age who is or plans on becoming pregnant during the course of the study * Patients with diabetes * Patients known to have a condition that in the investigator's judgment precludes participation in the study. * Patients who have received an investigational drug or have used an investigational device in the 30 days preceding to study entry
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06022848