Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
RecruitingNot applicableNCT06544525
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia. In subjects with normal function of the descending pain pathway, the net-effect during CPM testing is anti-nociceptive, or inhibition of the ascending pain pathway. In those with impaired descending pain pathway function, the response to CPM testing is pro-nociceptive, indicating that the body is unable to inhibit the pain signal, or may even amplify it. There is literature that supports the presence of impaired CPM, and therefore impaired descending pain pathway function, in numerus chronic pain conditions, including low back pain. Impaired descending pain pathway function may be contributing to this chronic pain presentation. This study will give us information on whether a typical physical therapy plan of care is able to improve impaired CPM, and if CPM values are predictive of improvement in physical therapy.
Study details
- Official title
- Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
- Conditions
- Interventions
- Sponsor
- Brooke Army Medical Center
- Start date
- 2024-09-19
- Primary completion
- 2025-07
- Sex
- All
- Age range
- from 18 Years to 64 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * DEERS eligible * English speaking * Age 18-64 years * ODI baseline ≥25% * NPRS baseline ≥3/10 * Low back pain symptoms greater than 3 months * Must be able to commit to at least six weeks of physical therapy interventions Exclusion Criteria: * Serious spinal pathology (acute fracture, active cancer, inflammation, inflammatory arthropathy) * Low back pain symptoms radiating below the knee * Pregnancy * Diagnosed neurological disease including traumatic brain injury, multiple sclerosis, chronic regional pain syndrome, and fibromyalgia. * History spinal surgery * Currently under litigation related to low back pain * Currently going through Medical Evaluation Board (MEB) * Retiring or separating from the military within a year
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06544525