Endogenous Pain Inhibition Deficiency in Chronic TMD Pain
RecruitingNCT06617494
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Temporomandibular disorders (TMDs) involve a range of conditions with varied causes, affecting a large portion of the U.S. population and posing challenges for diagnosis and management, especially in chronic cases. Despite advances in understanding TMD pathophysiology, the role of central sensitization, particularly deficient endogenous pain inhibition, remains unclear. The conditioned pain modulation (CPM) test, used to assess pain inhibition in chronic TMD pain, has produced inconsistent results due to varying testing parameters. The proposed cross-sectional study will investigate the efficiency of endogenous pain inhibition in individuals with chronic TMD pain compared to controls by applying noxious and non-noxious stimuli to facial and non-facial sites. The findings aim to clarify the impact of weaker pain inhibition over the face, how the conditioning stimulus' painfulness affects inhibition and the relationship between pain inhibition and fluctuations in TMD pain intensity.
Study details
- Official title
- The Role of Endogenous Pain Inhibition Deficiency in Chronic TMD Pain Pathophysiology
- Conditions
- Chronic Temporomandibular Disorders (TMD)
- Interventions
- Other: Pain modulation testing
- Sponsor
- University of Minnesota
- Start date
- 2024-09-16
- Primary completion
- 2026-12-31
- Sex
- All
- Age range
- from 18 Years to 74 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: To be eligible to participate in this study, an individual must meet all the following criteria: 1. Provide informed consent, documented in a signed and dated form. 2. Will comply with all study procedures, including daily ratings filling before and after the in-person study visit, and be available for the study duration. 3. All participants of both genders between ages 18 to 74 years. 4. Cases and controls will be matched for age within ±5 years, and all participants must understand English commands to follow study procedures (e.g., during CPM testing). Pain-free controls: 1. Age matching (within ±5 years) 2. No previous diagnosis for the most common pain-related TMD as defined in the DC/TMD criteria (myalgia, arthralgia, headache attributed to TMD) 3. No significant orofacial pain (jaw pain, TMJ pain) in the past 3 months (""significant"" meaning 5 or more days in any month or any pain during the past month) 4. No report of significant pain in the last 3 months elsewhere in the body (""significant"" meaning 5 or more days in any month or any pain during the past month), e.g., low back pain, fibromyalgia, migraine headaches 5. Not meeting any of the most common pain-related TMD diagnoses as described in the DC/TMD criteria (myalgia, arthralgia, headache attributed to TMD) upon clinical exam following the DC/TMD protocol Chronic painful TMD cases: 1. Primary TMD case criteria: Myalgia (masticatory muscle pain) based on clinical exam following the DC/TMD protocol 2. Concurrent arthralgia (TMJ pain) and/or headache attributed to TMD allowed 3. Myofascial pain must meet the following criteria: 1. Onset \>3 months, occurring \>15 days/month on average for \>3 months 2. Minimum of 10 jaw pain episodes since onset, each lasting at least 30 minutes and no less than 2 hours within the day, OR unremitting." Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Traumatic facial injury or surgery on the face/jaw, arms, or hands 2. Presence of pain related to dental and periodontal pathology 3. Pregnant 4. Has any of the following medical conditions by self-report: 1. Renal failure or dialysis 2. Heart disease (examples: uncontrolled arrhythmia or hypertension, cardiomyopathy) or heart failure 3. Non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema) 4. Diabetes (type I or II) that is not controlled with medication or diet 5. Hyperthyroidism 6. Uncont…
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06617494