Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain
Not yet recruitingNot applicableNCT06721988
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery. The main question it aims to answer is: • Does administration of oxycodone before surgical incision reduce the occurrence of chronic pain or relieve the chronic pain symptoms 3 months after the operation? Researchers will compare oxycodone + parecoxib sodium to placebo + parecoxib sodium combinations to see if oxycodone works to reduce the chronification of acute postoperative pain. Participants will: * Take oxycodone + parecoxib sodium or placebo + parecoxib sodium combinations before the surgical incision * Cooperate with the follow-up staffs and complete some checkups or tests within 3 months after the operation.
Study details
- Official title
- Exploring the Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Pain in Adult Patients Underwent Laparoscopic-assisted Abdominal Major Surgery
- Conditions
- Oxycodone
- Chronic Pain, Postoperative
- Interventions
- Drug: oxycodone and parecoxib sodium combinations
- Drug: Placebo and parecoxib sodium combinations
- Sponsor
- Ailin Luo
- Collaborators
- Jinhua Central Hospital; Minda Hospital of Hubei Minzu University; Taihe Hospital of Traditional Chinese Medicine; Qujing first people's Hospital
- Organization
- Tongji Hospital
- Start date
- 2025-01-01
- Primary completion
- 2026-12-31
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Total sites listed
- 0
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * ASA I\~III； * BMI ranging from 18 to 28 kg/m²； * For elective laparoscopic-assisted major abdominal surgery under general anesthesia; * Estimated surgical duration (from incision to the last suture of the skin) was at least 2 hours. Exclusion Criteria: * Pregnant or lactating patients; * Patients diagnosed with septic shock or multiple organ failure within 14 days; * Patients with preoperative severe electrolyte disorders; * Patients with stroke, transient ischemic attack, or other similar events within the past 3 months * Patients with unstable angina, myocardial infarction within the past 3 months; or presence of untreated arrhythmia or arrhythmia not well-controlled with treatment; * Patients with diabetes, uncontrolled blood glucose levels, or diabetes complications such as diabetic ketoacidosis, hyperosmolar coma, diabetes-related infections, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic peripheral neuropathy, diabetic foot, etc. before the surgery; * Patients with severe liver dysfunction (Child-Pugh score \> 6), renal dysfunction (GFR \< 90 ml/(min•1.73m²)); * Exploratory surgeries, day surgeries, or surgeries that only involve opening and closing the abdomen; * Blood pressure ≥180/110 mmHg at rest (≥Grade 3 hypertension according to the 2020 ISH Hypertension Guidelines); or systolic blood pressure \<90 mmHg or mean blood pressure \<65 mmHg; * Patients participated in other drug trials within the past 3 months; * Patients with communication difficulties, inability to understand pain scores or patient-controlled intravenous analgesia; * Patients with consciousness disorders or other psychiatric illnesses; * Patients with a confirmed or suspected history of substance abuse or long-term use of anesthetic sedatives and analgesics; * Cancer patients have received neoadjuvant treatment or chemotherapy preoperatively; * Allergic to the drugs used in this trial and their components.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06721988