Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
Not yet recruitingNot applicableNCT06858228
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies. The study evaluates the effectiveness and safety of continuous ablative radiofrequency, which uses heat energy to disrupt pain signals, and chemical denervation with absolute alcohol, which involves an injection to reduce pain transmission. Participants will be randomly assigned to one of the treatments, and their pain levels, mobility, and quality of life will be monitored over time to determine which method provides better pain relief.
Study details
- Official title
- Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: a Randomized Clinical Trial of Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
- Conditions
- Osteoarthritis Knee
- Chronic Pain
- Interventions
- Procedure: Continuous Ablative Radiofrequency
- Drug: Chemical Denervation with Absolute Alcohol
- Sponsor
- Federal University of São Paulo
- Start date
- 2025-04
- Primary completion
- 2026-09
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Brazil
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Adults aged ≥ 18 years. * Knee pain for more than 3 months. * Clinical and imaging-confirmed diagnosis of knee osteoarthritis, based on X-ray, ultrasound, or magnetic resonance imaging (MRI). Exclusion Criteria: * History of major joint interventions, such as previous knee surgery or arthroplasty. * Severe joint effusion. * Coagulation disorders or other clinical contraindications for the procedure. * Uncontrolled comorbidities that increase procedural risk. * Body mass index (BMI) \> 35. * Cognitive impairment that affects the ability to understand and respond to pain assessment instruments.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06858228