HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
CompletedNot applicableNCT06931158
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. This study will include patients with chronic low back pain. The main question it aims to answer is: How do rationales influence the effects of open-label placebos? Researchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.
Study details
- Official title
- Optimizing Open Placebos for Chronic Pain Patients
- Conditions
- Interventions
- Drug: Open-label Placebo
- Behavioral: Standard Rationale
- Behavioral: Mindfulness
- Behavioral: Control Rationale
- Sponsor
- Rhode Island Hospital
- Start date
- 2025-03-10
- Primary completion
- 2026-06-19
- Sex
- All
- Age range
- from 18 Years to 89 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion criteria are: * chronic pain (pain lasting at least 3 months, pain intensity 4/10 or over and interference 3/10 or over) * at least 18 years old * English speaking * have a smartphone or computer with video access * the chronic pain is concentrated into the patient's lower back (tentative criteria based on recruitment rate) Exclusion Criteria * Have chronic pain because of a cancer diagnosis * Over 89 years of age * Suspect an allergy to any placebo ingredient * Currently receiving worker's compensation.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06931158