Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)

Brief summary (from the registry)

This project aims to identify key cells and molecules involved in the development and modulation of neuropathic pain treated with spinal cord stimulation (SCS). By measuring concentrations of selected inflammatory mediators and signaling molecules (e.g., IL-1β, IL-6, IL-17, IL-33, BDNF, VEGF, GABA) in the blood and cerebrospinal fluid (CSF) of patients undergoing SCS, the study seeks to better understand the mechanism of action of SCS. The findings may allow the development of predictive biomarkers, help tailor stimulation parameters, and support complementary pharmacotherapy. The project also explores differences in response to various stimulation types and the role of glial cells in SCS efficacy, with a view to improving patient outcomes through more personalized neuromodulation strategies.

Study details

Official title

Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS) Assessment of the Mechanism of Action of SCS and the Potential of Biochemical Studies in Therapy Planning and Monitoring

Conditions

• Neuropathic Pain
• Chronic Pain
• Spinal Cord Stimulation (SCS)

Interventions

• Diagnostic test: Immunological Factors

Sponsor

Pawel Sokal

Collaborators

Department of Neurosurgery Collegium Medicum Nicolaus Copernicus University; Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz

Organization

Jan Biziel University Hospital No 2 in Bydgoszcz

Start date

2022-11-01

Primary completion

2026-09-30

Sex

All

Age range

from 18 Years to 80 Years

Results posted

No results posted in this snapshot

Countries

Poland

Total sites listed

1

Eligibility criteria