Skip to content

Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia

RecruitingNot applicableNCT07260864
View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation). Researchers are looking at how the parts of the brain that control movement (called motor cortices) respond to this treatment. The second goal is to find out if the changes in brain activity are different between the right and left sides of the brain, depending on which side gets the treatment.

Study details

Official title
Investigating the Differential Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Left and Right Motor Cortex in Fibromyalgia: A Prospective Randomized Trial With Functional Magnetic Resonance Imaging (MRI(
Interventions
  • Other: rTMS
Sponsor
University of Rochester
Start date
2025-12-05
Primary completion
2027-01
Sex
Female
Age range
from 18 Years to 65 Years
Results posted
No results posted in this snapshot
Countries
United States
Total sites listed
1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Female aged 18 to 65, right-handed, with no racial/ethnic restrictions. * A diagnosis of fibromyalgia by a qualified physician according to the American College of Rheumatology 2016 criteria * Must have a history of fibromyalgia pain for a duration ≥ 3 months, as it is included in the diagnostic criteria. * Must have pain intensity equal or greater than 4/10 on the numerical rating scale (NRS) at enrollment. * Concurrent chronic overlapping pain conditions (except migraine with aura), depression, and anxiety will be allowed when mild to moderate (Less than 31 on Beck Depression Inventory or less than 36 on Beck Anxiety Inventory), except in cases with psychotic or manic features. * Concomitant medication (except tricyclics, antipsychotic medications, bupropion, methadone, theophylline) and their doses for mood, pain and sleep disorders must be steady at least 4 weeks before enrolment and must be kept at a steady dosage during the trial. * Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires. * Must be in generally stable health. * Must sign an informed consent document after explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits, potential risks, and are willing to participate. Exclusion Criteria: * Inability to provide informed consent. * Age outside the studied range (i.e., \< 18, \> 65). * Patients planning to change their medications during trial. * Participants who are currently receiving other alternative therapies during trial (e.g., physiotherapy, acupuncture). * History of receiving TMS, transcranial direct current stimulation (tDCS), or electroconvulsive therapy (ECT). * Evidence of rheumatologic disorders, autoimmune diseases, taking immunosuppressive treatment, severe or unstable cardiac diseases. * Fibromyalgia must be the primary complaint; hence patients cannot have another main source of pain (e.g., osteoarthritis). Patients will be asked to shade all the areas in which they experience pain on a body map. If they shade areas other than typical fibromyalgia pain, we will discuss any previous diagnosis, the intensity and chronicity of pain, and exclude them if chronic pain in any area outside the condition in to be studied is confirmed. * Involvement in litigation regarding their pain or having a disability claim or receiving workman compensation or seeking either because of their pai…

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07260864