Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
Not yet recruitingNot applicableNCT07280975
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.
Study details
- Official title
- Comparative Outcomes of Polyglactin Versus Polypropylene Sutures for Rectus Sheath Closure: A Randomized Controlled Trial
- Conditions
- Chronic Pain
- Wound Dehiscence
- Surgical Site Infection (SSI)
- Incisional Hernia
- Rectus Sheath Closure
- Abdominal Surgery
- Interventions
- Procedure: Polyglactin 910 (Vicryl) Suture
- Procedure: Polypropylene (Prolene) Suture
- Sponsor
- Lady Reading Hospital, Pakistan
- Start date
- 2026-04-01
- Primary completion
- 2027-06-30
- Sex
- All
- Age range
- from 18 Years to 70 Years
- Results posted
- No results posted in this snapshot
- Countries
- Pakistan
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Age: 18-70 years. 2. Type of Surgery: Patients undergoing elective or emergency midline laparotomy. 3. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II). 4. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form. 5. Availability for Follow-Up: Participants must be available for 6 months follow-up. Exclusion Criteria: 1. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds. 2. Immunocompromised Conditions: Patients on steroids, chemotherapy, or those with HIV. 3. Previous Midline Laparotomy with Incisional Hernia: Patients who have a history of incisional hernia after midline laparotomy. 4. Severe Malnutrition: Patients with BMI \< 16 kg/m² or albumin \< 2.5 g/dL. 5. Emergency Laparotomy with Hemodynamic Instability: Patients who are unstable or in a critical condition. 6. Pregnancy: Pregnant women. 7. Need for Temporary Abdominal Closure or Planned Reoperation: Patients requiring staged reoperation or temporary closure.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07280975