Remote tDCS and Chair Yoga for Chronic Knee Pain in Alzheimer's Patients
RecruitingNot applicableNCT07303998
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study aims to evaluate the feasibility, acceptability, and preliminary effects of a home-based, remotely supervised intervention combining transcranial direct current stimulation (tDCS) and online chair yoga (OCY) to manage chronic knee pain in older adults with Alzheimer's Disease and Related Dementias (ADRD). Chronic knee pain is prevalent among individuals with ADRD and is often underdiagnosed and undertreated, contributing to neuropsychiatric symptoms, reduced quality of life, and increased caregiver burden. Current pharmacological options, such as opioids, pose risks of adverse events in this population. tDCS is a safe, noninvasive technique that uses low-intensity electrical current to modulate brain activity and may improve pain perception by targeting central mechanisms. Chair yoga is a mind-body intervention shown to improve pain and mood in older adults, including those with dementia. This study proposes that combining tDCS and OCY may have synergistic benefits in reducing pain and enhancing function. Participants will include older adults aged 60+ with mild to moderate ADRD and chronic knee pain, along with their caregivers. Over four weeks, participants will complete 14 supervised sessions of combined tDCS and OCY at home. Outcomes include feasibility, satisfaction, pain intensity, pain interference, neuropsychiatric symptoms, sleep disturbance, cognitive function, mobility, and quality of life. Neurophysiological measures (e.g., fNIRS, EEG, HF-HRV) will also be assessed to explore underlying mechanisms. This study seeks to lay the foundation for future large-scale randomized controlled trials of home-based nonpharmacological interventions for chronic pain in ADRD.
Study details
- Official title
- Feasibility and Effect of Remotely Supervised Transcranial Direct Current Stimulation With Chair Yoga for Chronic Knee Pain Management in Older Adults With Alzheimer's Disease and Related Dementias.
- Conditions
- Alzheimer&Amp
- #39
- s Disease
- Other Dementias
- Interventions
- Device: Active tDCS paired with active online chair yoga
- Sponsor
- University of Arizona
- Start date
- 2025-03-04
- Primary completion
- 2026-08-20
- Sex
- All
- Age range
- from 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria (participants): * Live in the community (not institutionalized). * Have a diagnosis of Alzheimer's disease and related dementias (ADRD), including Alzheimer's disease, Lewy Body Dementia, Vascular Dementia, or Multiple Etiology Dementias (MED) diagnosed by a neurologist or other healthcare provider. * Be in mild to moderate ADRD, as indicated by a Quick Dementia Rating Scale (QDRS) score between 6 and 20.5. * Score above 10 on the Montreal Cognitive Assessment (MoCA). * Experience chronic knee pain (caregiver-reported average pain in the past 3 months \> 40 out of 100). * Have no planned changes to their medication regimen or other interventions for knee pain during the trial. * Agree to participate in both transcranial direct current stimulation (tDCS) and online chair yoga (OCY). * Be able to ambulate independently with minimal assistance (e.g., using a cane or walker) for participation in OCY and the Timed Up and Go (TUG) test. - -- Be English-speaking and able to understand verbal instructions (literacy not required). * Be able to consent for themselves or identify a legally authorized representative who can provide written informed consent. * Exhibit neuropsychiatric symptoms (e.g., apathy, agitation). * Be naïve to yoga and tDCS. Exclusion Criteria (participants): * a history of brain surgery, brain tumor, head trauma, seizure/epilepsy, stroke, cancer affecting the head, or intracranial metal implantation; * systemic rheumatic disorders, including rheumatoid arthritis, systemic lupus erythematosus, or fibromyalgia; * prosthetic knee replacement or non-arthroscopic surgery to the affected knee; * compromised skin integrity on the head in the area where electrodes will be placed; * serious comorbidities that preclude participation in tDCS or OCY (e.g., heart failure \[level IV\] causing shortness of breath on exertion); * hospitalization within the preceding year for neuropsychiatric illness that would impact knee pain or interfere with study procedures; * use of another neurostimulation device (e.g., spinal cord stimulator, cardio-stimulator, or implanted cardioverter-defibrillator). Inclusion Criteria (caregivers): A caregiver is defined in this study as the person who provides care and assistance to a patient with ADRD (e.g., helping with daily activities, managing medications, ensuring safety). * Caregivers must be at least 18 years old * have provided care and assistance to the patient for at least 10 hours per week at the time …
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07303998