Central Sensitisation in Nociceptive and Neuropathic Pain
Active, not recruitingNCT07321080
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions. Chronic pain is a complex and multidimensional phenomenon involving sensory, cognitive, emotional, and behavioral components, often sustained by mechanisms of central sensitization that contribute to pain persistence and treatment resistance. Using a multidimensional assessment approach, the study integrates self-report questionnaires, neuropsychological evaluation, psychological measures, treatment adherence assessment, and neurophysiological investigation through laser-evoked potentials (LEP). Participants will be evaluated at baseline and after 12 months to explore differences between pain types and longitudinal changes in central sensitization, cognitive functioning, emotional status, and engagement with treatment. The findings are expected to improve the understanding of neurobiological and psychosocial mechanisms underlying different chronic pain phenotypes and to support more personalized and effective pain management strategies.
Study details
- Official title
- The Experience of Nociceptive and Neuropathic Pain: Differences in Levels of Central Sensitization
- Conditions
- Chronic Pain
- Nociceptive Pain
- Neuropathic Pain
- Mixed Pain (Nociceptive and Neuropathic)
- Interventions
- Behavioral: Neuropsychological assessment
- Behavioral: Laser evoked potentials
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
- Start date
- 2025-12-15
- Primary completion
- 2027-12-15
- Sex
- All
- Age range
- from 18 Years to 90 Years
- Results posted
- No results posted in this snapshot
- Countries
- Italy
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Age between 18 and 90 years * Presence of chronic pain * Diagnosis of nociceptive pain, neuropathic pain, mixed pain, or nociplastic pain * Patients referring to the pain outpatient clinic * Patients hospitalized in pain therapy units * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Presence of severe psychiatric disorders * Presence of severe neurological disorders * Presence of oncological diseases in terminal stage
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07321080