Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste
CompletedNot applicableNCT07340944
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study aimed to evaluate the efficacy of N-acetylcysteine (NAC) used as an intracanal medicament on antibacterial activity, periapical RANKL/OPG ratio, and postoperative pain levels.
Study details
- Official title
- Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste on Postoperative Pain Level, Periapical RANKL/OPG Ratio, and Antibacterial Activity
- Conditions
- Chronic Apical Periodontitis
- Interventions
- Drug: N Acetyl Cysteine
- Drug: Calcium Hydroxide (Ca(OH)2)
- Drug: Double Antibiotic Paste
- Sponsor
- Ataturk University
- Start date
- 2022-09-10
- Primary completion
- 2023-01-09
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Non-vital teeth confirmed by clinical and pulp sensitivity tests * Teeth with a single canal and diagnosed with asymptomatic apical periodontitis * Periapical assessment (PAI) of 2 or greater * Teeth with a pocket depth not exceeding 3 mm * Teeth without excessive root curvature (Schneider class 1) and with visible root canals on radiographs * Permanent teeth with complete root development * Patients between the ages of 18 and 65 * Teeth without previous endodontic treatment Exclusion Criteria: * Patients who refused to participate in the study * Patients with any systemic disease * Patients who received antibiotic treatment within the last 3 months * Patients who were pregnant or suspected of being pregnant * Teeth with excessive crown damage that would not allow for the placement of a rubber dam * Teeth with root fractures, pathological findings or mobility, * Presence of any resorption in the involved tooth, * Patients with active swelling and tenderness to palpation.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07340944