Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
RecruitingNot applicableNCT07425457
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Study details
- Official title
- Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty
- Conditions
- Arthroplasty
- Replacement Material
- Knee Arthritis Osteoarthritis
- Knee Arthroplasty, Total
- Genicular Nerves
- Chronic Pain
- Interventions
- Procedure: CT-guided Cryoneurolysis of the Genicular Nerves
- Sponsor
- Attikon Hospital
- Start date
- 2026-01-02
- Primary completion
- 2027-12-31
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Greece
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Adults ≥18 years undergoing primary TKA for osteoarthritis. * Cognitively normal and able to self-assess pain and function. * Provide written informed consent. Exclusion Criteria: * Cancer-related knee pain. * Neurological, psychiatric, or medical conditions interfering with assessment. * Chronic opioid users.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07425457