Genetic Alterations From Physical Therapy in Low Back Pain and Disc Degeneration
CompletedNot applicableNCT07439874
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Background and Scientific Rationale: This prospective randomized controlled trial examines the combined effect of physiotherapy and vitamin D supplementation on pain, disability, interleukin-6 (IL-6) expression, and vitamin D levels in individuals with chronic low back pain (CLBP). The study details the demographic and metabolic profiles of CLBP patients compared to healthy controls, addressing a previously underexplored aspect of chronic musculoskeletal pain therapy. A total of 100 patients with chronic low back pain and 100 healthy controls were enrolled. Sixty patients with chronic low back pain were randomly assigned to either receive physiotherapy alone (which included interferential therapy and exercise) or to undergo physiotherapy combined with vitamin D supplementation over six weeks. The outcomes measured included the Numeric Pain Rating Scale (NPRS), the Arabic Oswestry Disability Index (AODI), serum IL-6 expression, and serum vitamin D levels, assessed at baseline and after the intervention.
Study details
- Official title
- Genetic Alterations Induced by the Physical Therapy Intervention in the Pathogenesis of Low Back Pain and Intervertebral Disc Degeneration of Tabuk Population, Saudi Arabia
- Conditions
- Genetic Alteration
- Low Back Pain
- Physiotherapy
- Interventions
- Device: Interferential therapy
- Device: Interferential therapy
- Sponsor
- University of Tabuk
- Start date
- 2024-08-15
- Primary completion
- 2025-03-25
- Sex
- All
- Age range
- from 20 Years to 70 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Saudi Arabia
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * The study involves participants with LBP for more than 3 months. * Both genders, aged 20 to 70 years * Pain intensity of 4 or greater on the Numeric Pain Rating Scale * Capable of understanding and following instructions. Exclusion Criteria: * Skeletal deformities * Rheumatologic conditions * Progressive motor weakness * Incontinence * A history of cancer Use of systemic medications and illnesses Fractures.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07439874