Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery
Not yet recruitingNot applicableNCT07490457
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing open-heart surgery under general anesthesia. The main questions it aims to answer are: Primary outcome: Does a single-dose intraoperative IV ketamine reduce the presence and severity of pain at 3 and 6 months after surgery ? Secondary outcomes: Does it reduce acute postoperative pain scores, opioid consumption, and other recovery-related outcomes in the early postoperative period ? Researchers will compare a single-dose IV ketamine arm to a placebo arm to see if ketamine decreases chronic pain incidence at 3 and 6 months and improves acute pain/opioid-related outcomes. Participants will: Be randomized to receive either a single IV bolus of ketamine or placebo during surgery. Undergo standard general anesthesia and open cardiac surgery per protocol. Have postoperative pain assessed using Numeric Rating Scale (NRS) at extubation, 0, 3, 6, 12, 24, and 48 hours. Have opioid and additional analgesic use recorded, time to first rescue analgesic noted, and ICU/hospital length of stay tracked. Be evaluated for ICU delirium (CAM-ICU) and complete Quality of Recovery-15, Brief Pain Inventory-Short Form, and Pain Self-Efficacy questionnaires. Be followed up at 3 and 6 months for assessment of chronic postoperative pain.
Study details
- Official title
- Effect of Intraoperative Ketamine Administration on Postoperative Chronic Pain in Patients Undergoing Open Cardiac Surgery
- Conditions
- Cardiac Anaesthesia
- Chronic Pain
- Post Operative Pain, Chronic
- Post Operative Pain, Acute
- Ketamine
- Pain
- Interventions
- Other: Ketamine group
- Other: Control Group
- Sponsor
- Bursa City Hospital
- Start date
- 2026-04-15
- Primary completion
- 2027-03
- Sex
- All
- Age range
- from 18 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * ASA II-III, * Patients scheduled for elective on-pump open cardiac surgery via median sternotomy. Exclusion Criteria: * Emergency surgery requirement * Need for reoperation * Requirement for postoperative re-intubation * History of opioid use * Preoperative diabetic neuropathy or autonomic dysfunction * Hepatic or renal dysfunction * History of neuropathic pain * Neurocognitive disorders such as psychosis or dementia * Use of antidepressants or antipsychotics * Body mass index (BMI) \> 40
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07490457