Regenerative Endodontics in Mature Necrotic Teeth
Not yet recruitingNot applicableNCT07584928
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation protocols. The main question it aims to answer are: Does nanochitosan can demonstrate clinically successful outcome, minimize postoperative pain \& flare ups? What is the regenerative potential of mature necrotic teeth with chronic apical periodontitis? Is regeneration an alternative treatment modality for mature necrotic teeth with apical periodontitis? Researcher will compare the regenerative potential \& postoperative pain after using 2.5% NaOCl+ 17% EDTA, 1% nanochitosan \& 1% nanochitosan+17% EDTA to see if 1% nanochitosan alone or when used with 17% EDTA can enhance regeneration. Participants' root canals will be: Divided into 3 groups \&irrigated thoroughly by the different irrigation protocols (2.5% NaOCl+ 17% EDTA, 1% nanochitosan \& 1% nanochitosan+ 17% EDTA) Regenerative procedures will be done Clinical sensibility test \& radiographic changes will be evaluated at 6\&12 months follow up periods Detection of inflammatory mediators from GCF at 6 months follow up periods to be compared with its preoperative levels as a predictor for success or failure Assessment of postoperative pain using Numerical Rating Scale at 6, 12, 24 hours then daily for 7 days
Study details
- Official title
- Assessment of Clinical Success and Postoperative Pain of Mature Necrotic Teeth With Chronic Apical Periodontitis After Single Visit Regenerative Endodontics Using Different Irrigation Protocols: a Randomized Controlled Clinical Trial
- Conditions
- Necrotic Teeth With Chronic Apical Periodontitis
- Interventions
- Procedure: Intervention 1: 1% nanochitosan
- Procedure: Intervention 2: 1% nanochitosan & 17% EDTA
- Sponsor
- Suez Canal University
- Start date
- 2026-08-01
- Primary completion
- 2027-08-01
- Sex
- All
- Age range
- from 18 Years to 40 Years
- Results posted
- No results posted in this snapshot
- Countries
- Egypt
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: -adult patients in the age range 18-40 years with necrotic mature anterior teeth with chronic apical periodontitis as evidenced by apical radiolucency. * patients with good general health, without known systemic diseases or allergic reactions to any of the material used affecting healing outcome, with no sex predilection Exclusion Criteria: * medically compromised patients, systemic conditions e.g. uncontrolled diabetes or those on immunosuppressive drugs. * pregnant females * patients with generalized chronic periodontitis, mobility, and deep pockets * non-restorable teeth or teeth with open apices * teeth where post is needed to be restored or with previous root canal therapy * teeth with developmental anomalies, external and internal resorption
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07584928