Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain
CompletedNot applicableNCT07598994
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this clinical trial is to compare the effectiveness and safety of topical capsaicin cream and topical diclofenac gel in women with chronic temporomandibular joint-related pain. The main questions it aims to answer are: * Does topical capsaicin reduce pain intensity more effectively than topical diclofenac? * Do the treatments improve jaw function, pressure pain threshold, and neuropathic pain symptoms? Researchers will compare topical capsaicin cream with topical diclofenac gel to evaluate differences in pain relief and functional improvement. Participants will: * Apply the assigned topical medication four times daily for 7 days * Attend clinical examinations and pain assessments at baseline, Day 8, and Month 1 * Complete pain-related questionnaires and functional jaw measurements during follow-up visits
Study details
- Official title
- Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain: A Randomized, Prospective, Single-Blind Clinical Trial
- Conditions
- Temporomandibular Disorders (TMD)
- Temporomandibular Pain
- Interventions
- Drug: Capsaicin Topical Cream
- Drug: Diclofenac 1% Topical
- Sponsor
- Istanbul University
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Start date
- 2025-08-28
- Primary completion
- 2026-04-06
- Sex
- Female
- Age range
- from 18 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Female participants aged between 18 and 65 years * Diagnosis of temporomandibular disorder (TMD)-related pain * Presence of pain for at least 3 months * Baseline pain intensity sufficient to require treatment * Willingness to comply with study procedures and follow-up visits * Signed informed consent form Exclusion Criteria: * Pregnancy or breastfeeding * History of allergy or hypersensitivity to capsaicin or diclofenac * Presence of systemic inflammatory or neurological disease * Use of systemic analgesics, corticosteroids, or muscle relaxants during the study period * Active skin lesions or dermatologic disease in the application area * Previous temporomandibular joint surgery * Participation in another clinical trial within the last 30 days * Inability to comply with study procedures
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07598994