Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation
Not yet recruitingNot applicableNCT07618689
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Cryoablation is a minimally invasive treatment that produces controlled nerve injury using extreme cold. Although the freezing effect is localized around the cryoprobe, axonal interruption followed by distal Wallerian degeneration may extend functional denervation distal to the ablation site. This study aims to compare two ultrasound-guided cryoablation strategies for chronic neuroma pain after combat-related amputation: cryoablation performed directly near the neuroma and cryoablation performed proximal to the neuroma along the affected nerve. The study will evaluate whether proximal nerve cryoablation produces greater or longer-lasting analgesic effects compared with perineuroma cryoablation.
Study details
- Official title
- Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation
- Conditions
- Neuroma
- Cryoablation
- Interventions
- Procedure: Perineuroma Cryoablation
- Procedure: Proximal Nerve Cryoablation
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
- Start date
- 2026-10-15
- Primary completion
- 2026-10-15
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- Ukraine
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Age ≥18 years * Combat-related limb amputation * Chronic neuroma pain lasting ≥3 months * Ultrasound-confirmed painful neuroma * Average pain intensity ≥4/10 on Numeric Rating Scale * Positive Tinel sign * Ability to undergo ultrasound-guided cryoablation * Stable analgesic regimen for at least 14 days * Ability to provide written informed consent Exclusion Criteria: * Active infection at the treatment site * Open wound preventing safe procedure * Previous cryoablation of the target nerve within 6 months * Neuroma surgery within 3 months * Severe coagulopathy or anticoagulation contraindicating procedure * Pregnancy or breastfeeding * Severe uncontrolled systemic disease * Inability to complete follow-up assessments
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07618689