Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels
CompletedPhase 4NCT07683520
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study aimed to evaluate the effect of oral administration of probiotics as an adjunctive treatment to local intracanal medicaments, namely propolis and calcium hydroxide or empty canal, on the levels of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG), as well as on postoperative pain following root canal retreatment of teeth with chronic apical periodontitis
Study details
- Official title
- The Effect of Systemic Administration of Probiotics and Intra-Canal Medications on Level of Nuclear Factor Kappa B Ligand, Osteoprotegerin and Postoperative Pain in Patients With Chronic Apical Periodontitis: (Randomized Controlled Clinical Trial)
- Conditions
- Chronic Apical Periodontitis
- Interventions
- Dietary supplement: Linex Adult®
- Drug: Ca(OH)2 as intracanal medicament
- Other: Placebo
- Drug: propolis intracanal medication
- Other: Empty canal
- Sponsor
- Ain Shams University
- Start date
- 2025-10-04
- Primary completion
- 2026-06-04
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- Egypt
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Previously treated failed single rooted teeth with chronic apical periodontitis. * No use of antibiotic three months before treatment. * Patients are free of any systemic disease. * Positive patient acceptance for participation Exclusion Criteria: * Teeth that are badly broken down with difficult isolation. * Signs of acute infection, root fracture, root surface caries, swellings or ankylosis * Periodontally affected teeth with pockets deeper than 4mm. * Pregnant or lactating woman. * Patients who needs any prophylactic antibiotic. * Patients with allergy to pollen.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07683520