Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis
RecruitingNCT07707609
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology. Increasing evidence suggests that persistent pain is not solely driven by peripheral pancreatic abnormalities but also by central sensitization, involving maladaptive changes in central nervous system pain-processing pathways. While altered brain connectivity and neurochemical changes have been demonstrated in other chronic pain disorders, these mechanisms remain poorly characterized in CP. This study aims to integrate clinical phenotyping with blood-based metabolite profiling and advanced neuroimaging, including resting-state functional MRI and magnetic resonance spectroscopy, to investigate the relationship between central sensitization, brain dysfunction, and neuropsychological alterations. The findings may identify objective neurobiological markers of pain and facilitate the development of mechanism-based, personalized treatment strategies for patients with chronic pancreatitis.
Study details
- Official title
- Evaluation Of The Relationship Between Neural Sensitisation And Neuropsychological Alterations In Patients With Painful Chronic Pancreatitis
- Conditions
- Interventions
- Diagnostic test: Comprehensive Neuropsychological Assessment
- Diagnostic test: Resting-State Functional MRI (fMRI)
- Diagnostic test: Magnetic Resonance Spectroscopy (MRS)
- Diagnostic test: Blood-Based Metabolite Profiling
- Sponsor
- Asian Institute of Gastroenterology, India
- Start date
- 2026-01-06
- Primary completion
- 2026-11-06
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- India
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Diagnosed with CP confirmed by CECT, MRCP, or EUS based on Cambridge or Rosemont criteria. * Age 18-60 years. * Both genders Exclusion Criteria: * Recent episode of acute pancreatitis or ongoing pain (VAS \>5). * Pancreatic cancer and other significant comorbidities. * Recent use of antidepressants, anxiolytics, high-potency opioids, or neuromodulators. * Pregnancy and lactation. * Inability to give informed consent.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07707609