10% Dextrose Versus Triamcinolone Injections After Pulsed Radiofrequency for Herniated Nucleus Pulposus
CompletedNot applicableNCT07757321
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Lumbar herniated nucleus pulposus (HNP) is a common cause of chronic low back pain and radiculopathy. Transforaminal epidural steroid injection is commonly used as an adjuvant following pulsed radiofrequency (PRF) treatment but is associated with potential steroid-related adverse effects. Ten percent dextrose has been proposed as a regenerative, non-steroidal alternative. This single-blind randomized controlled trial compares the effectiveness of transforaminal epidural 10% dextrose versus triamcinolone administered after PRF in reducing pain, disability, and neuropathic pain in patients with lumbar HNP over a 14-day follow-up period.
Study details
- Official title
- Comparison Between 10% Dextrose Injection and Triamcinolone as an Adjuvant to Pulsed Radiofrequency of the Dorsal Root Ganglion in Patients With Herniated Nucleus Pulposus
- Conditions
- Herniated Nucleus Pulposus
- PRF
- Interventions
- Drug: 10% Dextrose Injection
- Drug: Triamcinolone Injection
- Sponsor
- Universitas Indonesia
- Start date
- 2025-12-05
- Primary completion
- 2026-05-20
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Countries
- Indonesia
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Adults aged 18-65 years. * Diagnosed with lumbar herniated nucleus pulposus (HNP) confirmed by magnetic resonance imaging (MRI). * Chronic low back pain and/or radicular pain for at least 3 months. * Numeric Rating Scale (NRS) pain score ≥4. * No indication for surgical intervention. * Eligible for pulsed radiofrequency of the dorsal root ganglion with transforaminal epidural injection. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Previous lumbar spine surgery. * Progressive neurological deficits or cauda equina syndrome. * Indication for immediate spinal surgery. * Known hypersensitivity to dextrose, triamcinolone, local anesthetics, or study medications. * Coagulation disorders or current anticoagulant therapy that cannot be safely discontinued. * Local or systemic infection. * Pregnancy or breastfeeding. * Uncontrolled diabetes mellitus or other severe uncontrolled systemic disease. * Severe psychiatric illness or cognitive impairment affecting study participation. * Participation in another interventional clinical trial. * Inability or unwillingness to complete the scheduled follow-up assessments.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07757321