S1R Imaging-Based Cryoneurolysis in Chronic Pain
Not yet recruitingEarly phase 1NCT07768501
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this clinical trial is to determine whether a sigma-1 receptor PET/MRI scan can help identify the specific nerves responsible for chronic pain. Researchers will use an investigational imaging agent called \[18F\]FTC-146 to look for signs of pain generating nerve irritation or injury that may not be visible on convention imaging tests. Participants whose pain-generating nerve can be identified may undergo a diagnostic nerve block and, if successful, a standard clinical procedure called cryoneurolysis will be used to temporarily interrupt pain signals.
Study details
- Official title
- Molecular Imaging-Based Cryoneurolysis: Targeting Upregulated Sigma-1 Receptor Positive Nerves in Chronic Pain
- Conditions
- Chronic Pain
- Mixed Pain (Nociceptive and Neuropathic)
- Interventions
- Drug: [18F]-FTC-146
- Sponsor
- Davidzon, Guido, M.D.
- Collaborators
- Society of Interventional Radiology Foundation
- Organization
- Stanford University
- Start date
- 2026-09
- Primary completion
- 2029-09
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Total sites listed
- 0
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Chronic nociceptive, neuropathic, or mixed pain for ≥2 months 2. Pain originating from a region amenable to cryoneurolysis (celiac plexus, intercostal nerves, pudendal nerve, peripheral nerve block 3. Chronic pain ≥2 months 4. Pain score ≥4/10 5. Pain location amenable to cryoneurolysis 6. Willing and able to provide consent. Exclusion Criteria: 1. Pregnancy or nursing. 2. Non-English speaking individuals 3. Contraindication to MRI scanning which includes, but is not limited to, incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ. 4. Weight \>350 pounds or a large body habitus, which the MR scanner cannot accommodate. 5. Claustrophobia or feeling that he or she will be unable to lie still in the scanner for a period of 2 hours or fit in the PET/MR scanner due to body size.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07768501