Comparison Between Radiofrequency,Hydrodissection and Cryoneurolysis in Chronic Ankle Pain
Not yet recruitingNot applicableNCT07778589
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Ligamentous injuries of the ankle are common among athletes. Inversion injuries of the ankle account for 40% of all athletic injuries. The anterior talofibular ligament (ATFL) and the calcaneofibular ligament (CFL) are sequentially the most commonly injured ligaments when a plantar-flexed foot is forcefully inverted. The posterior talofibular ligament (PTFL) is rarely injured, except in association with a complete dislocation of the talus. Eighty percent of patients with lateral ankle injuries make a full recovery following conservative rehabilitation. Up to 20% of patients with an acute inversion injury develop chronic functional instability. Electromyography (EMG) has demonstrated prolonged reaction times of the peroneal muscle in this group of patients. Strengthening and proprioception exercises can lead to improvement. Patients whose injury does not respond and who have continued mechanical laxity and functional instability may be candidates for lateral ligament reconstruction Chronic pain of the lower extremity remains challenging to manage.Non-Surgical Treatments include * Physical therapy: Do strength, flexibility, and balance exercises to build support around the joint. * Bracing and support: Wear an ankle brace or use custom shoe inserts (orthotics) to stabilize your foot. * Activity changes: Swap high-impact sports like running for low-impact options like swimming or cycling. * Medications: Take nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen to manage swelling and pain. * Injections: Get targeted corticosteroid or regenerative injections if recommended by a doctor. * Neuromodulaion : RFA, Cryneurolysis, botulinum injection Hydrodissection with botulinum toxin Hydrodissection is a minimally-invasive procedure that involves injecting fluid into anatomic spaces to facilitate dissection and adhesiolysis during surgery as proposed by Graesser et al. in 2022. In the past decade, it has been applied to the management of nerve entrapments by injectin…
Study details
- Official title
- Analgesic Efficacy of Radiofrequency Versus Hydrodissection or Cryoneurolysis of the Superficial Peroneal Nerve in Chronic Ankle Pain Following Anterior Talofibular Ligament Injury in Athletes: A Randomized Comparative Trial
- Conditions
- Chronic Ankle Pain in Athletes
- Interventions
- Procedure: Radiofrequency ablation
- Procedure: Hydrodissectipn with botilonum toxin
- Procedure: Cryoneurolysis
- Sponsor
- Assiut University
- Start date
- 2026-10-20
- Primary completion
- 2029-10-20
- Sex
- All
- Age range
- from 18 Years to 45 Years
- Results posted
- No results posted in this snapshot
- Total sites listed
- 0
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Athletes aged 18-45 years * Chronic ankle pain (\>6 months) following ATFL injury * Clinical and imaging confirmation of ATFL injury * No surgical indication (complete tear, associated fracture) * Failure of conservative treatment Exclusion Criteria: * Previous ankle surgery * Peripheral neuropathy or systemic neurological disease * Contraindications to botulinum toxin, RF ablation, or cryoneurolysis * General exclusion criteria for intervention (local infection, coagulopathy, patient refusal) * long standing condition \>5 y
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07778589