Evaluation of Temporomandibular Disorders During Pregnancy
Not yet recruitingNCT07791173
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study aims to evaluate how temporomandibular disorders (TMD) - a condition affecting the jaw joint and chewing muscles - change during pregnancy. The same pregnant women will be assessed twice: once in the first trimester (weeks 8-12) and again in the third trimester (weeks 28-32). At each visit, researchers will examine jaw function and pain, and collect blood samples to calculate inflammation markers from routine complete blood counts. Where participants additionally consent, blood samples will also be used to measure hormone levels (estrogen and progesterone). Participants will also complete questionnaires about pain, stress and jaw-related habits. The goal is to better understand whether hormonal and inflammatory changes during pregnancy are associated with the development or worsening of TMD symptoms.
Study details
- Official title
- Evaluation of Temporomandibular Disorders During Pregnancy
- Conditions
- Temporomandibular Disorders (TMD)
- Pregnancy
- Sponsor
- Zeynep Serra Kalkan
- Collaborators
- Bursa Yuksek Ihtisas Training and Research Hospital
- Organization
- Biruni University
- Start date
- 2026-09
- Primary completion
- 2027-03
- Sex
- Female
- Age range
- from 18 Years to 40 Years
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Aged 18-40 years * Singleton, healthy pregnancy * Presenting to the Obstetrics and Gynecology outpatient clinic during the first trimester (weeks 8-12) * No history of systemic rheumatic disease, chronic pain syndrome, or serious psychiatric illness * No prior orthodontic treatment * Written informed consent after being informed about the purpose and scope of the study Exclusion Criteria: * Prior treatment for temporomandibular disorders (splint, botulinum toxin, surgery, etc.) * History of maxillofacial trauma or temporomandibular joint surgery * Systemic rheumatic disease, connective tissue disease, or chronic pain syndrome * Use of systemic corticosteroids or hormone replacement therapy * Pregnancy achieved through assisted reproductive techniques (e.g., IVF) * Refusal to consent to blood sampling or questionnaire administration * Language barrier preventing understanding and completion of Turkish-language questionnaires
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07791173