COMT and IL6 Genotype-Phenotype Associations in Fibromyalgia and Myofascial Pain Syndrome
CompletedNCT07840963
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Fibromyalgia (FM) and myofascial pain syndrome (MPS) are chronic pain conditions that may share some clinical features but differ in the distribution and extent of pain and associated symptoms. The biological factors contributing to these differences remain incompletely understood. This observational study aims to compare the distribution of two pain-related genetic variants, COMT rs4680 and IL6 rs1800795, between individuals with FM and MPS and to investigate their associations with clinical characteristics. Participants will undergo standardized clinical assessment, including measures of symptom burden, physical functioning, and energy/fatigue. In participants with MPS, musculoskeletal ultrasonography will be used as an adjunct to clinical examination to support phenotypic characterization. Genetic analysis will be performed using DNA obtained from peripheral venous blood. COMT rs4680 and IL6 rs1800795 will be genotyped using a TaqMan probe-based real-time polymerase chain reaction method. The study is intended to explore genotype-phenotype associations in two clinically characterized chronic pain conditions. The investigated genetic variants are not being evaluated as diagnostic tests, and no intervention is assigned as part of the study.
Study details
- Official title
- Integrating Ultrasound-Supported Phenotyping With Comt Rs4680 And Il6 Rs1800795 Genotype-Phenotype Associations İn Fibromyalgia And Myofascial Pain Syndrome
- Conditions
- Fibromyalgia Syndrome
- Myofascial Pain Syndrome (MPS)
- Sponsor
- Istanbul Aydın University
- Start date
- 2026-03-19
- Primary completion
- 2026-07-20
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Adults diagnosed with fibromyalgia (FM) according to the 2016 revised American College of Rheumatology (ACR) diagnostic criteria; or * Adults diagnosed with myofascial pain syndrome (MPS) based on standardized clinical examination, including identification of a symptomatic muscle, palpable taut band, and clinically relevant myofascial trigger point. Musculoskeletal ultrasonography was additionally performed in all participants with MPS as a supportive phenotyping method. * Ability to understand and complete the clinical assessment questionnaires. * Provision of written informed consent for participation and genetic analysis. Exclusion Criteria: * Presence of both fibromyalgia and myofascial pain syndrome or fulfillment of the 2016 revised ACR criteria for fibromyalgia in participants considered for the MPS group. * Presence of another medical, neurological, rheumatological, or musculoskeletal condition that could substantially interfere with pain assessment or clinical phenotyping. * Inability to complete the study assessments. * Insufficient or unsuitable blood sample for genetic analysis.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07840963