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Degenerative Disc Disease: clinical trials and information

"Degenerative Disc Disease" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 27 chronic pain registry records worldwide.
1
Trials with Canadian sites
0
Recruiting in Canada
27
Registry records worldwide

Degenerative Disc Disease clinical trials in Canada

1 trial, recruiting first
PhaseProvinces
Safety Study for An Artificial Disc Nucleus Replacement to Treat Chronic Low Back Pain
NCT04004156
TerminatedNot applicableQuebecSpinal Stabilization Technologies2019-03-01

Degenerative Disc Disease clinical trials worldwide (outside Canada)

26 trials, 5 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease
NCT06144970
Not yet recruitingPhase 1Kolon TissueGene, Inc.2027-01-19
Biologic Injection For Adults With Lumbar Disc Herniation
NCT07386548
RecruitingNot applicableUnited StatesWeill Medical College of Cornell University2026-08-30
"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)
NCT05508360
RecruitingNot applicableColombia, Costa Rica, Panama, Paraguay and 1 moreSpinal Stabilization Technologies2022-08-22
Brain Mechanisms Supporting Cannabis-induced Pain Relief
NCT04982965
RecruitingEarly phase 1United StatesUniversity of California, San Diego2021-05-07
LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant
NCT04631133
RecruitingDenmark, France, GermanyBACKBONE2019-04-17
Stem Cells vs. Steroids for Discogenic Back Pain
NCT04735185
WithdrawnNot applicableUnited StatesJohns Hopkins University2025-09-30
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
NCT06325566
Active, not recruitingPhase 3United StatesMesoblast, Ltd.2024-07-03
Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
NCT06053242
Active, not recruitingPhase 1, Phase 2United StatesCreative Medical Technology Holdings Inc2024-05-21
Postmarket Clinical Follow-Up Study on Arcadius XP L® Interbody Fusion Device
NCT05944081
WithdrawnGermanyAesculap AG2024-03-15
Discure Technologies Feasibility Study for DDD
NCT06127745
Unknown statusNot applicableDiscure Technologies Ltd.2024-01
Post Market Observational Trial for the PerQdisc Nucleus Replacement Device
NCT05105490
WithdrawnGermanySpinal Stabilization Technologies2021-12-31
Intra-discal Injection of Platelet-rich Plasma (PRP) Enriched With Exosomes in Chronic Low Back Pain
NCT04849429
CompletedPhase 1IndiaDr. Himanshu Bansal Foundation2021-09-10
The SPINUS II Study: Spinal Fusion for Multilevel SPECT/CT Positive Lumbar Degeneration
NCT04893720
Unknown statusCzechiaMilitary University Hospital, Prague2021-06-01
Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease
NCT04727385
Unknown statusNot applicableFranceGelmetix2020-09-15
Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy
NCT04141098
TerminatedNot applicableParaguaySpinal Stabilization Technologies2019-09-19
GDS Muscle and Articulation Chain Treatment for Chronic LBP and Spinal Stenosis
NCT04436003
CompletedNot applicableNorwayThe Hospital of Vestfold2018-11-14
AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain
NCT03263611
CompletedPhase 1United StatesAnGes, Inc.2018-02-26
Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain
NCT03709901
Unknown statusNot applicableUnited StatesVIVEX Biologics, Inc.2017-08-22
Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease
NCT03484403
CompletedNot applicableDallas VA Medical Center2015-12-14
Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain
NCT02412735
CompletedPhase 3Australia, United StatesMesoblast, Ltd.2015-03-06
Facet Wedge Post Market Study
NCT02203448
CompletedGermany, SlovakiaSynthes GmbH2014-05-01
Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain
NCT01290367
CompletedPhase 2Australia, United StatesMesoblast, Ltd.2011-08
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System
NCT01011816
TerminatedPhase 3United StatesSpinal Restoration, Inc.2010-03
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
NCT01502644
CompletedPhase 4United StatesBrigham and Women's Hospital2009-02
Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease
NCT00165893
CompletedPhase 4Emory University2004-09
Disc Prosthesis Versus Multidisciplinary Rehabilitation
NCT00394732
CompletedNot applicableNorwayUllevaal University Hospital2004-04

About Degenerative Disc Disease

What is Degenerative Disc Disease?

"Degenerative Disc Disease" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 27 chronic pain registry records worldwide.

How is Degenerative Disc Disease usually assessed?

Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.

What kinds of treatments are studied for Degenerative Disc Disease?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Degenerative Disc Disease clinical trials in Canada?

This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.