Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1386
CompletedPhase 1NCT00690079
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The study is being performed in order to learn more about the safety and tolerability of AZD1386. AZD1386 is primary intended for treatment of chronic pain.
Study details
- Official title
- A Phase I, Randomised, Double-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD1386 in Healthy Caucasian Young and Elderly Subjects After Oral Multiple Doses.
- Conditions
- Interventions
- Drug: AZD1386
- Drug: Placebo
- Sponsor
- AstraZeneca
- Start date
- 2008-02
- Primary completion
- 2008-10
- Sex
- All
- Age range
- from 20 Years to 80 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Healthy Caucasians, males or females aged ≥20 and ≤ 45 years or between 65 80 years. Female subjects must be surgically sterile or post-menopausal for at least 12 months prior to the enrolment visit. * Body Mass Index (BMI) of ≥18 to ≤ 30 kg/m2 and weight of ≥50 to ≤100 kg * Clinically normal physical findings including heart rate \> 45 bpm and laboratory values and normal resting ECG Exclusion Criteria: * History of somatic or psychiatric disease/condition, which may interfere with the objectives of the study. * History of severe allergy/hypersensitivity or symptoms/signs of ongoing allergy/hypersensitivity. * Subjects with a high decrease in blood pressure within 5 minutes when going from a supine to standing position.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT00690079