QTc and Perceived Sleep Follow up Among Chronic Pain Patients With Opiate Medication

Brief summary (from the registry)

QTc: Since the reports of three deaths attributed to Torsade de Point (TdP) related to treatment with the long-acting methadone derivative levomethadyl acetate HCl (LAAM), methadone has been scrutinized for any possible association with TdP. Since then, several studies among Methadone Maintenance Treatment (MMT) patients and chronic pain patients were done, reporting diverse results about possible association between methadone dose and QTc prolongation. Most studies however were cross-sectional and generally found insignificant clinical prolongation of QTc. A follow up studies are of importance, and although few studies have started evaluating QTc among MMT patients, none was done among chronic pain patients with no history of drug usage. One study of 8 chronic pain patients experiencing insufficient pain control or intolerable side effects during treatment with oral morphine switched to oral methadone showed insignificant modest increase QTc following 9 month. Perceived Sleep: Chronic pain patients as well as drug addicts are known to suffer from poor sleep. Some studies found possible relation to methadone dose, however, no causal association was found and importantly some also found association with duration of opiate usage before starting methadone when entry to MMT clinic. Thus, patients with no history of opiate addiction are an important interesting group that may help understand relation between methadone usage and sleep quality. However, sleep must be evaluate before opiate administration and a follow up study is needed

Study details

Official title

QTc and Perceived Sleep Follow up Among Chronic Pain Patients With Opiate Medication

Conditions

• Chronic Pain

Interventions

• Drug: Methadone

Sponsor

Tel-Aviv Sourasky Medical Center

Start date

2010-01

Primary completion

2010-12

Sex

All

Age range

from 18 Years to 90 Years

Results posted

No results posted in this snapshot

Countries

Israel

Total sites listed

1

Eligibility criteria