Prevention of Persistent Postsurgical Pain After Thoracotomy
CompletedPhase 4NCT01243801
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Postthoracotomy acute pain is followed by persistent postsurgical pain in 20-30% of the patients, defined as pain that lasts more than 3-6 months after surgery. Acute pain and hyperalgesia around the surgical wound are some of the risk factors associated to the development of chronic pain. Ketamine, as a NMDA antagonist mainly at spinal level, might reduce periincisional hyperalgesia and persistent postsurgical pain after thoracotomy. Therefore, the investigators hypothesized that continuous ketamine infusion at subanesthetic dose would potentiate epidural ropivacaine and fentanyl-induced analgesia after thoracotomy, reduce periincisional hyperalgesia and long-term postoperative pain. To test these hypothesis, the investigators administered a low dose of intravenous ketamine or epidural ketamine or placebo to patients who received an epidural infusion of ropivacaine and fentanyl for postthoracotomy pain.
Study details
- Official title
- Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine
- Conditions
- Persistent Pain
- Postoperative Hyperalgesia
- Interventions
- Sponsor
- Hospital Clinic of Barcelona
- Start date
- 2008-09
- Primary completion
- 2011-10
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Spain
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patients over 18 years old submitted to thoracotomy or minithoracotomy expected to be extubated in the operating room Exclusion Criteria: * Allergy or intolerance to ketamine, local anesthetics or opioids * Chronic preoperative pain * Chronic opioid treatment * Drug addiction * Polyneuropathy * Ischemic cardiopathy * Psychiatric disease
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01243801