Drug: Ketamine: chronic pain clinical trials
Registry records that list "Drug: Ketamine" as an intervention. Being studied does not mean an intervention works or is approved.
2
Trials with Canadian sites
1
Recruiting in Canada
39
Registry records in total
Trials in Canada
2 trials, 1 recruiting or not yet recruiting. Recruiting first.
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches NCT05306899 | Recruiting | Phase 3 | Ontario | University Health Network, Toronto | 2022-06-01 |
| Plasma Concentration of Ketamine and Norketamine . NCT02016664 | Completed | Not applicable | Ontario | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2014-04 |
Trials worldwide (outside Canada)
37 trials, 6 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery NCT07197684 | Not yet recruiting | Not applicable | Aga Khan University | 2026-03-16 | |
| The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD NCT06414356 | Recruiting | Phase 4 | United States | Margaux M. Salas, PhD | 2024-10-02 |
| (2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain NCT05864053 | Recruiting | Phase 1, Phase 2 | United States | Rush University Medical Center | 2024-09-19 |
| RIVER At Home Ketamine Protocols NCT06070766 | Recruiting | United States | RIVER Foundation | 2023-10-01 | |
| Ketamine Treatment Plans for Chronic Conditions NCT06038409 | Recruiting | United States | RIVER Foundation | 2023-01-01 | |
| Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer NCT05156060 | Recruiting | Phase 1, Phase 2 | United States | Natalie Lockney | 2022-01-24 |
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study NCT05945147 | Withdrawn | Phase 2 | United States | Stanford University | 2099-01-01 |
| Ketamine in Central Sensitization NCT07182032 | Withdrawn | Phase 4 | United States | University Hospitals Cleveland Medical Center | 2026-02-01 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression NCT06317636 | Active, not recruiting | Phase 4 | United States | Stanford University | 2025-01-28 |
| Observational Study of Ketamine Infusions for the Treatment of Chronic Pain NCT05477004 | Enrolling by invitation | United States | Theresa Lii | 2022-06-01 | |
| Infusion Treatments of Chronic Peripheral Neuropathic Pain NCT06297915 | Completed | Turkey (Türkiye) | Hacettepe University | 2022-05-17 | |
| The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study NCT05229653 | Terminated | Phase 1 | United States | NYU Langone Health | 2022-04-12 |
| Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery NCT04220489 | Terminated | Phase 2 | United States | Jacques E. Chelly | 2019-12-17 |
| Ketamine to Improve Recovery After Cesarean Delivery - Part 1 NCT04037085 | Completed | Phase 2 | United States | Grace Lim, MD, MS | 2019-10-09 |
| Ketamine Sickle Cell Disease NCT03502421 | Withdrawn | Phase 3 | University of South Florida | 2018-09-01 | |
| Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain NCT03280017 | Completed | Phase 4 | Thailand | Mahidol University | 2017-09-25 |
| Lidocaine-Ketamine for Management of Chronic Pain NCT03249025 | Unknown status | Not applicable | Hamilton Health Sciences Corporation | 2017-09-01 | |
| Prevention of Post Mastectomy With Intraoperative Ketamine NCT03090776 | Completed | Early phase 1 | United States | Brigham and Women's Hospital | 2017-07-01 |
| Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain NCT02920528 | Completed | Phase 3 | United States | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 2017-05-01 |
| Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain NCT03915938 | Completed | Phase 2, Phase 3 | Hospital de Clinicas de Porto Alegre | 2017-01-02 | |
| Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy NCT02653651 | Completed | Phase 4 | Tunisia | University Tunis El Manar | 2016-01 |
| Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain NCT02527083 | Completed | Phase 4 | VA Pittsburgh Healthcare System | 2015-01 | |
| Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting NCT02303847 | Unknown status | Phase 3 | United States | University of Washington | 2014-11 |
| The Effect of Ketamine Infusion on Lumbar Surgery NCT02154438 | Unknown status | Phase 4 | South Korea | Yonsei University | 2014-05 |
| Ketamine in Chronic Kid's (KiCK) Pain NCT01755169 | Terminated | Phase 2 | United States | Medical University of South Carolina | 2013-01 |
| Methadone and Ketamine for Neuropathic Pain Treatment NCT02233452 | Completed | Phase 4 | Brazil | Universidade Federal de Santa Maria | 2012-01 |
| Oral Ketamine for Control of Chronic Pain in Children NCT01369680 | Completed | Phase 1 | United States | University of Rochester | 2011-05 |
| Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention NCT01296347 | Completed | Phase 4 | United Kingdom | Imperial College Healthcare NHS Trust | 2011-04 |
| The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy NCT02969733 | Completed | Phase 2, Phase 3 | France | University Hospital, Lille | 2011-01 |
| Acute and Chronic Pain, Especially Neuropathic Pain, After Thoracotomy and Continuous Application of Ketamine. NCT03105765 | Completed | Not applicable | Germany | Dr. Horst Schmidt Klinik GmbH | 2011-01 |
| Oral Ketamine Administration in Patients With Peripheral Neuropathic Pain NCT00961194 | Completed | Phase 2 | France | University Hospital, Toulouse | 2009-03 |
| Effect of Ketamine on Opioid-Induced Hyperalgesia NCT00833755 | Completed | Not applicable | United States | Massachusetts General Hospital | 2008-09 |
| Prevention of Persistent Postsurgical Pain After Thoracotomy NCT01243801 | Completed | Phase 4 | Spain | Hospital Clinic of Barcelona | 2008-09 |
| Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients NCT01591382 | Completed | Phase 4 | United States | Brigham and Women's Hospital | 2008-09 |
| The Effect of Perioperative Ketamine on Acute and Chronic Pain After Major Back Surgery NCT00618423 | Completed | Phase 2 | Switzerland | University Hospital, Geneva | 2007-10 |
| Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain NCT00899600 | Completed | Not applicable | United States | Dartmouth-Hitchcock Medical Center | 2007-02 |
| Preemptive Low-dose Epidural Ketamine for Preventing Chronic Post-thoracotomy Pain NCT01017393 | Completed | Not applicable | South Korea | Seoul National University Hospital | 2004-04 |
Conditions studied with this intervention
- Chronic Pain13 trials
- Neuropathic Pain5 trials
- Pain, Chronic4 trials
- Postoperative Pain3 trials
- Acute Pain3 trials
- Chronic Low Back Pain2 trials
- Pain, Postoperative2 trials
- Pain, Acute2 trials
- Pain, Neuropathic2 trials
- Endometriosis2 trials
- Anxiety Disorders2 trials
- Chronic Disease2 trials
- Pain1 trials
- Hyperalgesia1 trials
- Chronic Postoperative Pain1 trials
- Chronic Pain Syndrome1 trials
- Chronic Pain, Widespread1 trials
- Opioid Use1 trials
- Opioid Dependence1 trials
- Post Operative Pain1 trials
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.